广东汉族人群RXRG rs1467664位点与2型糖尿病遗传易感性的关联研究  

Association between genetic polymorphisms of RXRG rs1467664 and genetic susceptibility of type 2 diabetes in Guangdong Han population

作　　者：于海兵 王姝 胡维 何小艺 闫妍 潘海燕 何玉清 孔丹莉 林子牛 王燕 丁元林 Yu Haibing;Wang Shu;Hu Wei;He Xiaoyi;Yan Yan;Pan Haiyan;He Yuqing;Kong Danli;Lin Ziniu;Wang Yan;Ding Yuanlin(Department of Epidemiology and Health Statistics,Guangdong Medical University,Dongguan 523808, China)

机构地区：[1]广东医科大学流行病与卫生统计学教研室,东莞523808 [2]广东医科大学基础医学院微生物与免疫学教研室,东莞523808 [3]广东医科大学系统生物研究所,东莞523808 [4]深圳中迈数字医疗技术有限公司,518000

出　　处：《国际遗传学杂志》2018年第6期439-444,共6页International Journal of Genetics

基　　金：国家自然科学面上基金(81273166);广东省医学科研基金(B2018074);广东省科技发展专项资金(基础与应用基础研究方向)博士科研启动项目(2018A030310115);广东高校省级重点平台和重大科研特色创新类项目(2017KTSCX084);广东医科大学博士学位人员和人才引进人员科研启动项目(自然科学类)(B2017010);2018年东莞市社会科技发展(一般)项目(20185071521339);深圳市技术创新计划技术攻关项目(JSGG20160331103247408);广东医学院自然科学类重点培育项目(Z2015004);广东省中医药局科研基金(20161141);广东省自然科学基金(2016A030313674);东莞市社会科技发展项目(2016108101028);2018年广东省大学生创新创业训练计划项目(201810571102).

摘　　要：目的对维甲酸X受体γ(retinoid X receptor gamma,RXRG)基因rs1467664位点的单核苷酸多态性与2型糖尿病(type 2 diabetes mellitus,T2DM)遗传易感性的关联性进行研究。方法采用病例-对照研究,利用SNPscan^TM 分型技术检测1092例2型糖尿病患者和1092名正常对照者RXRGrs1467664位点的基因型,运用SPSS20.0软件对该位点基因型及等位基因频率在两组中的分布进行分析。结果RXRGrs1467664位点基因型和等位基因在两组间的分布差异无统计学意义。在调整年龄、体质指数(body mass index,BMI)、性别前后,两组间rs1467664位点的各遗传模型差异均无统计学意义(P>0.05)。结论RXRGrs1467664位点单核苷酸多态性与广东地区汉族人群2型糖尿病患者遗传易感性不存在明显相关性。Objective To investigate the relationship between RXRG rs1467664 and genetic susceptibility to type 2 diabetes mellitus. Methods A case-control study was used. Genotypes of RXRG rs1467664 in 1092 patients with type 2 diabetes mellitus and 1092 normal controls was detected by SNPscan^TM. Genotype and allele frequencies were analyzed by SPSS 20.0 software. Results There was no significant difference in allele frequency and genotype frequency of RXRG rs1467664 between case and control groups. Before and after adjusting for age, gender, and BMI, there was no statistically significant difference in rs1467664 in genetic models between the two groups (P>0.05). Conclusion Our result suggested that there is no significant association between RXRG rs1467664 and genetic susceptibility to type 2 diabetes mellitus in Guangdong Han population.

关 键 词：2型糖尿病 单核苷酸多态性 RXRG基因 

分 类 号：R587.1[医药卫生—内分泌]