病毒载体在神经干细胞中的应用和发展  

Application and development of viral vectors in neural stem cells

作　　者：李玲[1] 孙长慧 王雪[1] 惠洋[1] 高旭[1] Li Ling;Sun Changhui;Wang Xue;Hui Yang;Gao Xu(Department of Biochemistry and Molecular Biology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室,150081

出　　处：《国际遗传学杂志》2018年第6期518-523,共6页International Journal of Genetics

基　　金：国家自然科学基金(81671255).

摘　　要：病毒载体是生物医学研究和基因治疗中细胞遗传修饰的理想工具。是当今基因工程研究的热点之一,载体是可以插入目的基因并将其导入宿主细胞内表达或复制的运输工具。利用病毒载体可以治疗一些特殊的疾病,同时探索病毒载体所面临的安全性和毒性问题。目前研究最多的是逆转录病毒、慢病毒、腺病毒和腺相关病毒系统。本文将对以上四种病毒载体在神经干细胞上的应用和发展作一综述。The viral vector is an ideal tool for cell genetic modification in biomedical research and gene therapy. It is one of the hotspots in the research of genetic engineering. The vector is a transportation tool for inserting and transferring the target gene into the host cell. The virus vector could cure incurable diseases and explore the safety of the viral vector and toxic problems. At present, more researches are retrovirus, lentivirus, adenovirus, adeno-associated virus vector system. In this review, application and development of the above four viral vectors in neural stem cell were reviewed.

关 键 词：病毒载体 基因治疗 神经干细胞 应用 

分 类 号：R450[医药卫生—治疗学]