EB病毒及人巨细胞病毒近期感染参与系统性红斑狼疮疾病活动临床分析  

Clinical analysis of recent epstein-barr virus and human cytomegalovirus infection in disease activity of systemic lupus erythematosus

作　　者：杨大伟 臧欢欢 黄玉萍[1] 孙旭 李莹[1] YANG Da-wei(The second affiliated hospital of Bengbu Medical College, Bengbu,Anhui,233300,China)

机构地区：[1]蚌埠医学院第二附属医院,安徽蚌埠233300 [2]蚌埠医学院第一附属医院

出　　处：《齐齐哈尔医学院学报》2018年第18期2109-2113,共5页Journal of Qiqihar Medical University

摘　　要：目的通过分析EB病毒(EBV)、人巨细胞病毒(HCMV)近期感染与系统性红斑狼疮(SLE)临床特征的相关性,为EBV、HCMV参与SLE疾病活动提供证据。方法选取2014年1月—2018年3月我院收治的85例SLE患者,根据EBV和HCMV检测结果,分为病毒感染组和非病毒感染组,研究变量包括两组患者一般资料如年龄、性别、病程;临床特征,如发热、关节炎、皮肤黏膜损害、肾脏受累、肺损害、肝损害、血液系统损害、浆膜炎等,反应疾病活动的实验室检验结果;如抗双链DNA抗体、补体C3、补体C4、血沉等;以及SLEDAI2000积分等。结果病毒感染组和非病毒感染组年龄、病程差异均无统计学意义(P>0.05)。病毒感染组其发热率显著增加(χ~2=7.02,P<0.05),血液系统损害率显著增加(χ~2=7.93,P<0.05),肝功能损害率显著增加(χ~2=7.78,P<0.05),皮肤损害率显著升高(χ~2=5.63,P<0.05);肺损害率显著增加(χ~2=6.13,P<0.05);补体C4水平显著降低(t=2.76,P<0.05);血沉显著升高(t=2.99,P<0.05);且疾病活动指数(SLEDAI2000)显著升高(t=4.24,P<0.05),差异有统计学意义。两组肾脏受累率、关节炎发生率、浆膜炎发生率、补体C3水平、抗双链抗体阳性率差异无统计学意义(P>0.05)。结论近期EBV、HCMV感染作为致病因素参与SLE的疾病活动。尽早抗EBV、HCMV感染治疗,为控制SLE疾病活动提供新的诊疗思路。Objective To provide evidence for epstein-barr virus( EBV) and human cytomegalovirus( HCMV) infection in the pathogenesis and progression of Systemic Lupus Erythematosus( SLE) by analyzing the correlation between EBV and HCMV Infection and clinical feature of SLE.Methods A total of 85 SLE patients admitted in the second affiliated hospital of Bengbu medical college from January 2014 to March 2018 were enrolled in this study. According to the EBV and HCMV detection results,85 SLE patients were divided into viral infection group and non-viral infection group. The study variables included the general data of the two groups,such as age,gender and course of disease. Clinical feature: fever,central nervous system damage,skin damage,renal damage,lung damage,liver damage,hematological damage,arthritis,serositis etc. Related laboratory results: anti-double chain antibody,complement C3,complement C4,serum albumin,and SLEDAI2000 score.Results There was no significant difference in age and course of disease between the virus infected group and the non-virus infected group( P>0.05). In the virus infected group,the fever rate increased significantly( χ^2= 7.02,P<0.05),as well as the hematological damage rate( χ^2= 7.93,P<0.05),liver function damage rate( χ^2= 7.78,P<0.05),skin lesions rate( χ^2= 5.63,P<0.05),lung damage rate( χ^2= 6.13,P< 0.05),blood sedimentation( t= 2.99,P< 0.05) and disease activity index( SLEDAI2000)( t = 4.24,P< 0.05). However,the level of complement C4 decreased significantly( t = 2. 76,P < 0. 05). There was no statistically significant difference in renal involvement rate,arthritis rate,serositis rate,complement C3 level,and anti-double chain antibody positive rate between the two groups( P>0.05).Conclusions Recent EBV and HCMV infection plays a role as pathogenic factors participate in the disease activity of SLE,and the early anti-EBV and HCMV treatment provide new diagnostic and therapeutic ideas for the control of SLE disease activity.

关 键 词：红斑狼疮 EB病毒 人巨细胞病毒 疾病活动度 

分 类 号：R373[医药卫生—病原生物学]