溶血性贫血的发病机制及中药治疗作用研究进展  

Research progress in pathogenesis of hemolytic anemia and its treatment with traditional Chinese medicine

作　　者：颜磊 何小燕[1,2] 徐向平 黄胜 颜冬兰 秦雪梅 田俊生[1,2,3] YAN Lei;HE Xiao-yan;XU Xiang-ping;HUANG Sheng;YAN Dong-lan;QIN Xue-mei;TIAN Jun-sheng(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030005,China;Shanxi Key Laboratory of Active Constituents Research and Utilization of Traditional Chinese Medicine,Taiyuan 030005,China;Jiuzhitang Co.,Ltd.,Changsha 410205,China)

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]地产中药功效物质研究与利用山西省重点实验室,山西太原030006 [3]九芝堂股份有限公司,湖南长沙410205

出　　处：《中国中药杂志》2018年第18期3652-3657,共6页China Journal of Chinese Materia Medica

基　　金：中国博士后科学基金面上项目(2016M602414);山西省科技研究计划项目(201603D321077,201603D3113013,201601D011122,201701D22111344);山西省科技创新重点团队项目(201605D131045-18);山西省重点实验室项目(201605D111004)

摘　　要：溶血性贫血是临床常见疾病,发病原因具有多样化,发病率也逐年上升。临床常用免疫抑制剂或切除脾脏进行治疗,虽有一定的疗效,但也伴随着明显地机体损伤和不良反应等问题。中药对溶血性贫血具有较好的治疗作用,在提高疗效的同时也减少了不良反应,具有疗效高、作用温和、价格低廉等优势。该文对溶血性贫血的发病机制以及中药复方、单味药和单体成分治疗溶血性贫血的药理作用与机制进行综述,以期为疾病临床合理治疗及中药作用机制现代研究提供科学依据。Hemolytic anemia is a common clinical disease with diverse pathogenesis. In recent years,the incidence of hemolytic anemia is increasing dramatically. The present clinical treatment of immunosuppressive agents or splenectomy is effective to some extent;however,the accompanied clinical adverse reactions are also significant. Traditional Chinese medicine( TCM) has beneficial therapeutic effect on hemolytic anemia,with the obvious advantages including curative effect,less adverse reactions,and low price.The pathogenesis of hemolytic anemia as well as the pharmacological effects and mechanisms of the compound,single herb,and monomer composition of TCM in the treatment of hemolytic anemia were reviewed,aiming to provide the basis for the clinical treatment of hemolytic anemia and the modern research on the mechanism of TCM.

关 键 词：溶血性贫血 发病机制 中药治疗 研究进展 

分 类 号：R259[医药卫生—中西医结合]