红葱鳞茎中1个新的萘酚类化合物  

A new naphthalene derivative from bulbs of Eleutherine americana

作　　者：陈德力[1] 李榕涛[1] 刘洋洋[1] 杨峻山[1] 许旭东[1] 马国需[1] CHEN De-li;LI Rong-tao;LIU Yang-yang;YANG Jun-shan;XU Xu-dong;MA Guo-xu(Hainan Branch Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences &Peking Union Medical-College,Haikou 570311,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & PekingUnion Medical College,Beijing 100193,China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所海南分所

出　　处：《中国中药杂志》2018年第18期3683-3687,共5页China Journal of Chinese Materia Medica

基　　金：海南省重点研发计划项目(ZDYF2017127);海南省自然科学基金创新研究团队项目(2017CXTD022)

摘　　要：采用硅胶柱色谱及半制备高效液相色谱对红葱鳞茎石油醚部位进行化学成分研究,并通过MS,UV,IR,NMR等波谱技术鉴定其结构。从红葱鳞茎石油醚部位分离得到4个化合物,分别鉴定为红葱酚B(1)、4,8-二羟基-3-甲氧基-1-甲基蒽醌-2-羧酸甲酯(2),8-羟基-3,4-二甲氧基-1-甲基蒽醌-2-羧酸甲酯(3)和异红葱乙素(4),其中1为新化合物。10μmol·L-1浓度下化合物1和2的舒张血管作用较强,达到了82.5%和85.3%,与阳性药丹参酮ⅡA(86.3%)基本一致。A new naphthalene derivative and three known compounds were isolated from the petroleum ether extract of the bulbs of Eleutherine americana by using various chromatographic techniques,such as column chromatography over silica gel and semi-preparative HPLC. Their structures were elucidated by spectroscopic date( MS,UV,IR,NMR),which were identified as eleutherol B( 1),4,8-dihydroxy-3-methoxy-1-methylanthraquinone-2-carboxylic acid methyl ester( 2),8-hydroxy-3,4-dimethoxy-1-methylanthraquinone-2-carboxylic acid methyl ester( 3),and isoeleutherine( 4). Compound 1 is a new compound. The diastolic blood vessels activity of compound 1 and 2 were potent,reaching 82. 5% and 85. 3% at the concentration of 10 μmol·L-1,which were basically the same as that of the positive drug tanshinoneⅡA.

关 键 词：黎药 红葱 萘衍生物 化学成分 

分 类 号：R284.1[医药卫生—中药学]