难溶性中药纳米混悬剂的体内外行为研究进展  

Research progress on in vitro and in vivo behaviors of poorly soluble Chinese materia medica nanosuspension

作　　者：申宝德 沈成英[2] 徐玲霞[1] 朱卫丰 袁海龙 SHEN Bao-de;SHEN Cheng-ying;XU Ling-xia;ZHU Wei-feng;YUAN Hai-long(Key Laboratory of Modern Preparation of Traditional Chinese Medicine (TCM),Ministry of Education,Jiangxi University of TCM ,Nanchang 330004,China;Department of Pharmacy,Air Force General Hospital,PLA ,Beijing 100142,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004 [2]中国人民解放军空军总医院药学部,北京100142

出　　处：《中国中药杂志》2018年第19期3828-3833,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81803741,81873092,81573697);军队后勤科研重点项目(BKJ16J025)

摘　　要：纳米混悬剂(也可称为纳米晶体混悬剂或纳米晶)可通过减小粒径,增加比表面积,显著增加难溶性药物的饱和溶解度和溶出,改善其生物利用度,解决难溶性中药有效成分和有效部位的递送难题。该文在简要概括纳米混悬剂的制备方法的基础上,主要对难溶性中药纳米混悬剂的体内外行为研究进行综述,并对研究中存在的问题进行分析探讨,以期为难溶性中药纳米混悬给药系统的进一步研究提供借鉴和思考,促进纳米混悬技术在中药制剂中的发展和完善。Nanosuspension(also called nanocrystal suspension or nanocrystal) could significantly enhance the saturated solubility and dissolution of insoluble drugs, and improve their bioavailability by reducing particle size and increasing the specific surface, which could then solve the delivery problems of the poorly soluble active ingredients and effective parts of Chinese materia medica(CMM). Based on the brief summaries of nanosuspension preparation methods, this paper would mainly review the in vitro and in vivo behaviors of poorly soluble CMM nanosuspension, discuss and analyze its problems, so as to provide reference and thinking for the further study of nanosuspension drug delivery system of poorly soluble CMM and promote the development and perfection of nanosuspension technology in CMM.

关 键 词：中药 纳米混悬剂 制备方法 体内外行为 研究进展 

分 类 号：R283[医药卫生—中药学]