调节糖脂代谢的苦味中药的化学及生物学研究  

Chemistry and biology research on bitter-taste Chinese materia medica with function of regulating glycolipid metabolism

作　　者：卢方晋[1] 丁丽琴[2,3] 曹世杰 张德芹[2,3] 张伯礼[2,3] 邱峰[1,3] LU Fang-jin;DING Li-qin;CAO Shi-jie;ZHANG De-qin;ZHANG Bo-li;QIU Feng(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China)

机构地区：[1]天津中医药大学中药学院,天津300193 [2]天津中医药大学中医药研究院,天津300193 [3]天津中医药大学天津市现代中药重点实验室,天津300193

出　　处：《中国中药杂志》2018年第19期3834-3840,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81430095)

摘　　要：苦味是中药五味学说中的重要性味之一,具有泄下、燥湿和坚阴的功效特点。在常用中药中苦味药物占有很大的比例,表明苦味药物存在的重要性。中医临床上有很多善于运用苦味药物治疗糖尿病的实例,通过利用苦味清热燥湿、泻火解毒的特点,对应糖尿病阴虚燥热、痰湿内阻的病机进行治疗,取得了良好的效果,证实苦味中药调节糖脂代谢紊乱(糖尿病的主要特征)的确切作用。目前围绕具有糖尿病治疗作用的中药化学成分及其药理作用的研究报道较多,但是关于调节糖脂代谢苦味中药的化学和生物学的综述性研究较少。该文总结了治疗糖尿病苦味中药的药性特征及配伍特点,重点分析了具有调节糖脂代谢紊乱苦味中药的化学生物学的研究概况,为中药药性理论的深入研究奠定基础。The bitter taste is one of the important properties among five flavors of Chinese materia medica(CMM), characterized by downbearing and discharging, drying dampness, and consolidating Yin. In common CMM, bitter-taste CMM accounts for a large proportion, indicating the importance of it. Through the efficacy of clearing away heat and dampness, reducing fire and removing toxin, bitter-taste CMM has achieved good results in treating diabetes in clinical application, proving their definite therapeutic effect on regulating glucose and lipid metabolism(main features of diabetes). At present, there are many reports about the chemical constituents and pharmacological effects of CMM on diabetes, but there are few reviews on the chemistry and biology of bitter-taste CMM. This study summarized the properties and compatibility characteristics of bitter-taste CMM for treating diabetes, and mainly analyzed the chemistry and biology basis of bitter-taste CMM with function of regulating glycolipid metabolism, laying foundation for further researches on properties theory of CMM.

关 键 词：苦味药 调节糖脂代谢 糖尿病 化学成分 生物活性 信号通路 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]