前列环素的肾脏保护作用  

Research progress on renal protective effects of prostacyclin

作　　者：李菁[1] 郝传明[1] LI Jing;HAO Chuanming(Division of Nephrology,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院肾脏科,上海200040

出　　处：《肾脏病与透析肾移植杂志》2018年第6期565-569,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：前列环素(prostacyclin,PGI_2)是一种具有舒张血管和抗血小板聚集作用的前列腺素,其类似物对原发性肺动脉高压和周围血管疾病具有较好的疗效。新近研究发现,PGI_2对包括肾脏在内的多器官都具有抗炎、抗增殖、抗纤维化等作用,为拓宽其应用提供依据,本文就PGI_2在肾脏病领域的相关研究进展做一简述。Prostacyclin( PGI2) is a member of the prostaglandin family.The major effects of PGI2 are vasodilation and inhibition of platelet aggregation.PGI2 analogs are usually used to treat patients with pulmonary arterial hypertension and intermittent claudication.Some recent studies showed that the effects of PGI2 also include anti-inflammation,anti-proliferation and anti-fibrosis.This paper has reviewed progress about the basic researches and clinical trials of PGI2 in some kidney diseases,and the potential of PGI2 analogs as a therapy target of kidney diseases to improve clinical outcomes was also discussed.

关 键 词：前列环素 贝前列素钠 糖尿病肾病 对比剂肾病 

分 类 号：R692[医药卫生—泌尿科学]