手性Mn(Ⅲ)-Salen配合物催化的2-芳基环烷醇的高对映选择性氧化动力学拆分  

Highly enantioselective oxidative kinetic resolution of 2-arylcycloalkanols catalyzed by chiral Mn(Ⅲ)-salen complexes

作　　者：徐大乾[1] 孙强盛 夏春谷[1] 孙伟[1] Daqian Xu;Qiangsheng Sun;Chungu Xia;Wei Sun(State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China)

机构地区：[1]中国科学院兰州化学物理研究所,羰基合成与选择氧化国家重点实验室,兰州730000

出　　处：《中国科学：化学》2018年第12期1619-1626,共8页SCIENTIA SINICA Chimica

基　　金：中国科学院前沿科学重点研究计划(编号:QYZDJ-SSW-SLH051);国家自然科学基金(编号:21473226,21773273)资助项目.

摘　　要：本文发展了一种通过氧化动力学拆分获得光学活性2-芳基环烷醇的方法:该体系以N-溴代丁二酰亚胺为氧化剂,简单易得的手性Mn(Ⅲ)-salen配合物(0.5 mol%)为催化剂.该方法底物适用性广、具有高度的立体控制且易于进行克级规模的反应,为光学活性2-芳基环烷醇类化合物的合成提供了一种高效、实用的方法.A highly enantioselective method toward oxidative kinetic resolution of 2-arylcycloalkanols has been established, wherein easily available chiral Mn(Ⅲ)-salen complex(0.5 mol%) serves as an efficient catalyst and NBS as oxidant. This method represents a successful and practical example for enantioselective production of substituted 2-arylcycloalkanols owing to its broad substrate scope, high stereocontrol as well as easy extending to gram scale.

关 键 词：Mn(Ⅲ)-salen配合物 氧化动力学拆分 2-芳基环烷醇 N-溴代丁二酰亚胺 

分 类 号：O621.251[理学—有机化学]