乌鲁木齐地区肿瘤患者Lewis血型系统抗体筛查分析  

Analysis on Lewis blood group system irregular antibody screening of tumor patients in Urumqi

作　　者：刘潇[1] 桂霞[1] 郭琪[1] 孙晓洁[1] 赵星[1] 胡国龙[1] LIU Xiao;GUI Xia;GUO Qi;SUN Xiao jie;ZHAO Xing;HU Guo long(Department of Blood Transfusion,Xinjiang Medical University Affiliated Tumor Hospital,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院输血科,乌鲁木齐830011

出　　处：《新疆医学》2018年第11期1171-1173,共3页Xinjiang Medical Journal

基　　金：新疆医科大学附属肿瘤医院创新基金;(项目编号:肿2014-06)

摘　　要：目的对新疆乌鲁木齐地区肿瘤患者红细胞Lewis血型基因不规则抗体的发生率与临床疾病种类分布情况进行分析研究。方法对乌鲁木齐住院肿瘤患者共19903例血标本采用微柱凝胶免疫技术进行不规则抗体筛查,对抗体筛查阳性的标本采用盐水法、微柱凝胶抗球蛋白法进行特异性抗体鉴定,采用卡方检验统计学方法进行统计分析。。结果 19903例住院肿瘤患者血标本中共筛出Lewis血型系统抗体58例(0.29%):IgM类型42例,IgG类型16例;女性54例(0.27%),男性4例(0.02%),女性明显多于男性(P <0.05)。汉族37例(0.19%),维吾尔族16例(0.08%),其他民族5例(0.02%),汉族高于维吾尔族(P>0.05)。58例Lewis血型系统抗体中,妇科肿瘤(宫颈癌、子宫内膜癌、子宫肌瘤、畸胎瘤、盆腔肿物)36例(62.07%);肝胆外科疾病(肝癌、胰腺癌)8例(13.79%);乳腺外科(乳腺癌、乳腺增生、乳腺肿物)7例(12.07%);胃肠外科(直肠癌、胃癌、结肠癌、胃癌放化疗后)5例(8.62%);神经外科疾病(胶质瘤、垂体瘤、三叉神经瘤)2例(3.45%)。并且30例输血患者均未出现任何输血不良反应。结论乌鲁木齐为多民族聚居地区,对肿瘤患者进行Lewis血型系统不规则抗体的检测及鉴定,了解肿瘤患者Lewis血型系统不规则抗体的发生率、临床特异性分布特点及有无民族差异性对于保障临床用血,降低输血不良反应的发生有重要意义。Objective To analysis on Lewis blood group system irregular antibody positive rate and distribution among tumor patients. Methods A total of 19903 blood samples from hospitalized patients in Urumqi were screened for irregular antibodies by microcolumn gel immunoassay. The antibody positive samples were identified by the brine method and microcolumn gel antiglobulin method, and chi square test was used for statistical analysis. Results 58 cases(0.29%)of Lewis blood group system antibodies were screened out from the blood samples of 19903 hospitalized cancer patients: 42 cases of IgM type, 16 cases of IgG type, 54 cases of women(0.27%), 4 cases of men(0.02%)and significantly more women than men(P < 0.05). There were 37 cases of Han nationality(0.19%),16 cases of Uygur nationality(0.08%)and 5 cases of other nationalities(0.02%). Han nationality was higher than that of Uygur nationality(P > 0.05). Among 58 Lewis blood group system antibodies, 36 cases(62.07%)were gynecologic tumors(cervical cancer, endometrial cancer, uterine myoma, teratoma, pelvic mass);8 cases(13.79%)were hepatobiliary diseases(liver cancer, pancreatic cancer);7 cases(12.07%)were breast surgery(breast cancer, breast hyperplasia, breast mass);and gastrointestinal surgery(rectum)were 5 cases(8.62%)of cancer, gastric cancer, colon cancer and gastric cancer after radiotherapy and chemotherapy, and 2 cases(3.45%)of neurosurgical diseases(glioma, pituitary adenoma and trigeminal neuroma). And there were no adverse reactions in 30 blood transfusion patients. Conclusion Urumqi is a multi-ethnic area. The detection and identification of irregular antibodies in the Lewis blood group system of tumor patients are carried out to understand the occurrence rate, clinical specific distribution characteristics and ethnic differences of irregular antibodies in the Lewis blood group system of tumor patients, which is of great significance to guarantee clinical blood use and reduce the occurrence of adverse transfusion reactions.

关 键 词：肿瘤 Lewis血型基因不规则抗体 输血 

分 类 号：R457.1[医药卫生—治疗学]