Ti-Cu合金微弧氧化种植体的动物体内骨结合行为  

Osseointegration in animal bodies with Ti-Cu alloy micro-arc oxidation implants

作　　者：吴姗姗 刘继光[1] 李慕勤[1] 张二林 姚海涛[1] 迟艳侠[1] 李艳芳 WU Shanshan;LIU Jiguang;LI Muqin;ZHANG Erlin;YAO Haitao;CHI Yanxia;LI Yanfang(Key Laboratory of Biomedical Materials of Heilongjiang Province Colleges, Jiamusi University,Jiamusi Heilongjiang 154007,China;Key Laboratory for Anisotropy and Texture of Materials,Ministry of Education, School of Materials Science and Engineering,Northeastern University,Shenyang Liaoning 110819, China)

机构地区：[1]佳木斯大学黑龙江省高校生物医学材料重点实验室,黑龙江佳木斯154007 [2]东北大学材料科学与工程学院材料各向异性与织构教育部重点实验室,辽宁沈阳110004

出　　处：《中国体视学与图像分析》2018年第4期359-368,共10页Chinese Journal of Stereology and Image Analysis

基　　金：国家自然科学基金项目(编号:31370979)

摘　　要：目的探讨Ti-Cu合金种植体在动物体内的骨结合行为。方法 Ti合金种植体(Ti) A组,Ti-Cu合金种植体(Ti-Cu) B组,Ti-Cu合金-微弧氧化种植体(Ti-Cu-MAO) C组,分别植入家兔下颌骨内2周、4周、8周后取出带种植体的骨块,进行锥形束CT(CBCT)、扫描电镜(SEM)、能谱分析(EDS)、激光共聚焦显微镜等检测。结果 CBCT显示C组种植体周围骨密度明显高于A、B两组。扫描电镜及能谱分析表明C组新生骨明显增多且骨融合带处的Ca、P元素分布更为活跃。激光共聚焦显微镜观察三组骨结合率大小顺序为C组>B组>A组,并具有统计学意义。结论通过微弧氧化处理的Ti-Cu合金种植体能够促进骨结合,缩短愈合时间,增强种植体初期稳定性。Objective To investigate the osseointegration behavior of Ti-Cu alloy implants in animals.Methods Group A of Ti alloy implant(Ti),group B of Ti-Cu alloy implant(Ti-Cu),and group C of Ti-Cu alloy micro-arc oxidation implant(Ti-Cu-MAO) were implanted into the mandible of rabbits for2 weeks,4 weeks and 8 weeks,respectively. Then the bone blocks with implants were removed for analysis and investigation with cone beam CT(CBCT),scanning electron microscopy(SEM),energy spectrum analysis(EDS),and laser confocal microscopy. Results CBCT results showed that the bone density around the implants in group C was significantly higher than those in group A and group B. The results with scanning electron microscopy and energy spectrum analysis showed that the number of new bones in group C increased significantly and the distribution of Ca and P elements in the bone fusion zone was more active. The order of osseointegration rate in the three groups observed by laser confocal microscopy is group C > group B > group A with statistical significance. Conclusions Ti-Cu alloy implant treated by micro-arc oxidation can promote osseointegration,shorten the healing time and enhance the initial stability of implants.

关 键 词：Ti-Cu合金 种植体 微弧氧化 骨结合 动物实验 

分 类 号：TG146.23[一般工业技术—材料科学与工程] R318.08[金属学及工艺—金属材料]