乌索酸调节PI3K/AKT/mTOR信号通路在结直肠癌中的研究进展  

Progress in the Regulation of PI3K/AKT/mTOR Signaling Pathway by Ursolic Acid in Colorectal Cancer

作　　者：崔宏伟[1] 苏秀兰[1] Cui Hongwei;Su Xiulan(The Clinical Medical Research Center of the Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010050,China)

机构地区：[1]内蒙古医科大学附属医院临床医学研究中心,呼和浩特市010050

出　　处：《世界科学技术-中医药现代化》2018年第10期1882-1888,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金地区科学基金项目(81660468):生物活性肽ACBP介导miRNA调节胃癌干细胞作用机制及功能研究;负责人:苏秀兰

摘　　要：乌索酸(Ursolic acid,UA)是一种广泛存在于植物的草、叶、花和果实中的具有抗氧化,抗菌,抗炎,肝保护,免疫调节,抗肿瘤,化学预防,心脏保护、抗高脂血症和降低血糖等活性的五环三萜类化合物。本文综述了乌索酸结构与抗肿瘤机制、PI3K/AKT/mTOR信号通路参与结直肠癌进程以及乌索酸调节PI3K/AKT信号通路阻碍结直肠癌进展。Ursolic acid(UA) is an active pentacyclic triterpenoid widely found in grass, leaves, flowers and fruits of plants, which is antioxidant, antimicrobial, anti-inflammatory, hepatoprotective, immunomodulatory, anti-tumor,chemopreventive, cardioprotective and antihyperlipidemic and hypoglycemic. In paper, the ursolic acid structure, antitumor mechanism, PI3K/AKT/mTOR signaling pathway taking part in the process of colorectal cancer, and the regulation of PI3K/AKT/mTOR signaling pathway by ursolic acid in stopping the development of colorectal cancer was summarized.

关 键 词：乌索酸 PI3K/AKT信号通路 结直肠癌 

分 类 号：R285[医药卫生—中药学]