藏药大三果化学成分及药理作用研究进展  

Research Process of Chemical Constituents and Pharmacological Effects of Tibetan Medicine Triphala

作　　者：周坤[1] 简平 梁文仪 梁林金 崔雅萍 叶婷 张兰珍[1] Zhou Kun;Jian Ping;Liang Wenyi;Liang Linjin;Cui Yaping;Ye Ting;Zhang Lanzhen(Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学,北京102488

出　　处：《世界科学技术-中医药现代化》2018年第9期1608-1614,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上基金项目(81274187):基于藏药余甘子酚酸类成分体内动态变化的抗癌药效物质与质量控制研究;负责人:张兰珍;北京中医药大学校级科研纵向发展基金(2016-ZXFZJJ-065):藏药大三果鞣质部位提取纯化质量控制及抗肿瘤活性研究;负责人:张兰珍

摘　　要：藏药大三果由诃子、毛诃子和余甘子三味药组成,其成药为三果汤散。大三果富含多种化学成分,主要包括鞣质类、酚酸类、三萜类及黄酮类等。鞣质在大三果中含量丰富,常作为主要的分析指标。现代研究表明,大三果具有预防胃肠疾病、抗菌、抗炎、抗氧化、抗肿瘤等多种药理活性。本文结合近年来国内外的相关文献,对大三果的化学成分及药理作用进行简要综述,为大三果的开发及深入研究提供参考。Triphala consists of Terminalia chebula Retz, Terminalia bellirica(Gaertn.) Roxb. and Phyllanthus emblica L,which are made into Dasanguo Powder. Triphala is rich in a variety of chemical components, including tannins, phenolic acids, triterpenoids and flavonoids. The content of tannin is abundant in Triphala, which are often used as the main indicators of analysis. Modern research found that Triphala has a variety of pharmacological activities such as prevention of gastrointestinal diseases, antibacterial, anti-inflammatory, anti-oxidation, anti-tumor and so on. This paper briefly summarized the chemical constituents and pharmacological effects of Triphala, combining the relevant national and international literature in recent years to provide reference for the development and further study of Triphala.

关 键 词：大三果 鞣质 化学成分 药理作用 

分 类 号：R29[医药卫生—民族医学]