藏药毛诃子水溶性化学成分研究  

Study on Water-Soluble Constituents from Tibetan Medicine Terminalia billirica(Gaert.) Roxb

作　　者：李师[1] 梁文仪[1] 梁林金 叶婷 简平 周坤 张兰珍[1] Li Shi;Liang Wenyi;Liang Linjin;Ye Ting;Jian Ping;Zhou Kun;Zhang Lanzhen(College of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102448

出　　处：《世界科学技术-中医药现代化》2018年第9期1622-1626,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上基金项目(81274187):基于藏药余甘子酚酸类成分体内动态变化的抗癌药效物质与质量控制研究;负责人:张兰珍;北京中医药大学校级科研纵向发展基金(2016-ZXFZJJ-065):藏药大三果鞣质部位提取纯化质量控制及抗肿瘤活性研究;负责人:张兰珍

摘　　要：目的:研究藏药毛诃子Terminalia billirica(Gaert.) Roxb.水溶性部分化学成分。方法:利用大孔吸附树脂Diaion HP-20、凝胶Sephadex LH-20、Toyopearl HW-40、MCI gel CHP 20P、和ODS多种色谱技术分离纯化,根据化合物理化性质和波谱学数据进行结构鉴定。结果:从毛诃子水溶性部位分离得到10个化合物,分别鉴定为柯里拉京(Corilagin,1)、水杨苷(Salicoside,2)、甲基-α-阿拉伯糖苷(Methyl-α-D-arabinofuranoside,3)、1,4-二甲基-β-D-吡喃果糖(1,4-dimethyl-β-D-fructopyranose,4)、β-吡喃果糖(β-fructopyranose,5)和β-呋喃果糖(β-fructofuranose,6)、没食子酸(Gallic acid,7)、鞣花酸(Ellagic acid,8)1,2,3,4,6-五-O-没食子酰基-β-D-葡萄糖吡喃苷(1,2,3,4,6-penta-O-galloyl-β-D-glucopyranonside,9)、诃黎勒酸(Chebulagic acid,10)。结论:除化合物7和8外,其余均为首次从该植物中分离得到,化合物2-6为首次从榄仁树属植物中得到。This paper aimed at investigating the water-soluble constituents of Terminalia billirica(Gaert.) Roxb.Compounds were isolated and purified by Diaion HP-20, Sephadex LH-20, Toyopearl HW-40, MCI gel CHP 20 P and ODS column chromatographies. The chemical structures were elucidated according to spectral data and physicochemical properties. The results showed that ten compounds were isolated and identified as corilagin, salicoside, methyl-α-Darabinofuranoside, 1,4-dimethyl-β-d-fructopyranose, β-fructopyranose, β-fructofuranose gallic acid, ellagic acid, 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranonside, Chebulagic acid. Except compound 7 and 8,others compounds are separated from Terminalia billirica(Gaert.) Roxb for the first time, and except corilgin, the other compounds are separated from Terminalia for the first time.

关 键 词：毛诃子 水溶性成分 

分 类 号：R962[医药卫生—药理学]