血清Irisin水平与心衰的相关性研究  

Serum Irisin Level and its Correlation with Heart Function in Patients with Heart Failure

作　　者：巨敏[1,2] 吴丽丽 王蕊 王汝涛[1] 薛强[1] JU Mina;WU Li-liu;WANG Rui;WANG Ru-tao;XUE Qian(Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi,710032,China;Department of Cardiology,Shaanxi Geological Mining Hospital,Xi'an,Shaanxi,710014,China)

机构地区：[1]第四军医大学西京医院心血管内科,陕西西安710032 [2]陕西省地质矿产勘查开发局职工医院心内科,陕西西安710014

出　　处：《现代生物医学进展》2018年第23期4447-4451,共5页Progress in Modern Biomedicine

基　　金：陕西省社会发展基金项目(2015sf096)

摘　　要：目的:观察心衰患者血清IRISIN水平变化规律,研究Irisin对心衰诊疗的临床价值。方法:连续收集西京医院心内科住院的心衰患者132例,根据NYHA心功能分级将患者分为三组,其中心功能Ⅱ级48例,Ⅲ级44例,Ⅳ级40例,同时选取心功能正常(左室射血分数LVEF>50%)的30例健康体检者为对照组。采用酶联免疫吸附试验(ELISA)检测患者血清中Irisin水平,根据Irisin水平分为低Irisin组和高Irisin组,比较两组间心衰的发生率,分析Irisin水平与心衰的关系。结果:①心衰组Irisin水平显著低于心功能正常组(6790±3628 ng/mL vs 12691±2272 ng/mL,P<0.01),且从Ⅱ级到Ⅳ级,逐渐降低;②心衰组LVEF值显著低于心功能正常组(45.7±8 vs 59.7±4.3,P<0.01),且从Ⅱ级到Ⅳ级,逐渐降低;③心衰组N末端B型利钠肽原(ProBNP)水平显著高于心功能正常组(2938±2795 pg/mL vs 184±151 pg/mL,P<0.01),且从Ⅱ级到Ⅳ级,逐渐升高;④低Irisin组心衰发生率明显高于高Irisin组(92.6%vs47.5%,P<0.01);⑤单因素相关分析显示:血清Irisin水平与左室射血分数呈正相关(r=0.694,P<0.05),与proBNP呈负相关(r=-0.45,P<0.05);结论:心衰患者血清Irisin水平降低,而且随着心功能的恶化显著降低,心衰患者血清Irisin水平与心衰程度有一定的相关性。Objective: To observe the IRISIN level of heart failure patients, to research practical value of serum Irisin level in heart failure patients. Methods: A total of 132 patients with heart failure were collected from the department of Cardiology of Xijing Hospital.According to NYHA classification heart failure group were divided into 3 groups, 48 cases were cardiac function class Ⅱ, 44 patients cardiac function grade Ⅲ, 40 patients cardiac function level Ⅳ, and left ventricular ejection fraction(LVEF)>50% healthy control group of 30 cases were selected. Serum Irisin levels were measured by ELISA. According to serum Irisin levels, the patients were divided into low Irisin group and high Irisin group, to determine the relationships of Irisin and the heart function. Results:①Irisin in heart failure group was significantly lower than that in healthy control group(P<0.01), and from class Ⅱ to Ⅳ, gradually reduced;②LVEF in heart failure group than the healthy control group decreased significantly(P<0.01), and from class Ⅱ to Ⅳ, gradually decreased;③ProBNP in heart failure group was significantly lower than that in healthy control group(P<0.01), and increased gradually from class Ⅱ to Ⅳ in patients.④The incidence of heart failure in low Irisin group significantly increased compared with that of high group(92.6%vs47.6%,P<0.01).⑤ Single factor correlation analysis showed that Irisin was positively correlated with LVEF(r=0.694, P<0.05) and negative correlated with proBNP(r=-0.45, P<0.05). Conclusion: The concentration of serum Irisin in CHF patients decreased, and significantly decreased from class Ⅱ to Ⅳ, there was a correlation between degree of heart failure and serum Irisin levels.

关 键 词：Irisin 心衰 左室射血分数 B型利钠肽原 

分 类 号：R541.61[医药卫生—心血管疾病]