膀胱出口部分梗阻动物模型的研究进展  

Research Progress on Animal Model of Partial Bladder Outlet Obstruction

作　　者：陈林[1,2] 杨亚飞[2] 杨进[1] 何平林[1,2] 王凯 王云汉 汪自力[1] CHEN Lin;YANG Ya-fei;YANG Jin;HE Pin-lin;WANG Kai;WANG Yun-han;WANG Zi-li(Department of Urology,Affiliated Hospital of Chengdu University,Chengdu 610081,China;Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]成都大学附属医院泌尿外科,成都610081 [2]遵义医学院,遵义563000

出　　处：《实验动物与比较医学》2018年第6期463-467,共5页Laboratory Animal and Comparative Medicine

基　　金：国家自然科学基金项目(81500577);四川省科技厅资助项目(2017JY0098);成都市科技局项目(2015-HM01-00580-SF);成都市卫计委资助项目(2015123)

摘　　要：构建理想的膀胱出口部分梗阻(pBOO)动物模型是研究膀胱梗阻性疾病发病机制和开展药物治疗研究的关键。本文就pBOO动物模型的诱导方式选择(包括经耻骨上膀胱颈结扎法、尿道外口缝扎法、尿道外口皮下注射透明质酸等),及诱导pBOO动物模型的特点及局限性进行综述。Constructing an ideal animal model of bladder outlet partial obstruction(pBOO) is the key to study the pathogenesis of bladder obstructive diseases and conduct drug therapy research.In this article,we summarized the animal model induction methods,including the characteristics and limitations of animal models induced by suprapubic bladder neck ligation,extraurethral splenic suture,and subcutaneous hyaluronate injection outside the urethra,and the characteristics and disadvantages of induced pBOO model.

关 键 词：膀胱出口部分梗阻(pBOO) 动物模型 下尿路症状 尿动力学 

分 类 号：Q95-33[生物学—动物学]