国产聚丙烯尿失禁吊带植入兔腹壁及阴道的组织相容性研究  

Histocompatibility of an original Chinese-made mid-urethral sling in a rabbit model

作　　者：曹杨[1] 林丽敏 马骋 邓坤学 袁玉宇 徐弢[3] 朱兰[1] Cao Yan;Lin Limin;Ma Cheng;Deng Kunxue;Yuan Yuyu;Xu Tao;Zhu Lan(Department of Obstetrics and Gyneacology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Bering 100730,China;Medprin Regenerative Medical Technologies Co.Ltd,Shenzhen 518100,China;Department of Mechanical Engineering,Tsinghua Biomanufacturing Center,Beijing 100084,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院妇产科,100730 [2]深圳迈普再生医学科技有限公司,518100 [3]清华大学生物制造工程研究所,北京100084

出　　处：《中华妇产科杂志》2019年第1期44-48,共5页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的评价国产尿失禁吊带的组织相容性。方法10只雌性新西兰白兔分为2组(分别用于吊带植入后4周、12周的观察),每组分别于腹壁皮下深筋膜与肌肉间层、阴道与膀胱间隙手术植入国产尿失禁吊带或已上市的同类产品经闭孔无张力尿道中段悬吊带(TVT-O吊带),每只实验动物的腹壁和阴道植入的吊带均为同一种。于植入后4周、12周处死实验动物,获取吊带标本,进行组织学观察。结果所有实验动物吊带植入术后切口愈合良好,无排尿异常情况,术后功能活动正常。两种吊带植入实验动物体内后均与周围组织间形成薄层疏松结缔组织。吊带植入腹壁皮下后,国产尿失禁吊带和TVT-O吊带植入4周时的组织病理学评分中位数分别为10.5和10.5分,植入12周时的组织病理学评分中位数分别为10.0和9.5分,分别比较,差异均无统计学意义(P均>0.05)。吊带植入阴道与膀胱间隙后,国产尿失禁吊带和TVT-O吊带植入4周时的组织病理学评分中位数分别为6.0和12.0分,植入12周时的组织病理学评分中位数分别为8.5和12.5分,国产尿失禁吊带的组织病理学评分均低于TVT-O吊带,但差异均无统计学意义(P均>0.05)。结论国产尿失禁吊带更为轻薄,植入实验动物体内后显示了良好的组织相容性,尤其是在阴道原位植入后,国产尿失禁吊带局部反应小,有临床应用优势。ObjectiveTo evaluate the histocompatibility of an original Chinese-made mid-urethral sling (Repelvica mid-urethral sling). MethodsIn total 10 female New Zealand white rabbits were implanted with Repelvica mid-urethral sling or tension-free vaginal tape-obturator tape (TVT-O;Gynecare). Both brands of sling were implanted under deep fascia of the abdominal wall and in the space between vagina and bladder. All animal groups were sacrificed at set time intervals (4 weeks and 12 weeks), and the abdominal and vaginal slings were harvested for histological evaluation.ResultsAll slings appeared to be well incorporated into the abdominal wall and anterior vaginal wall. All specimens showed a thin, loose, fibrous interface between the synthetic graft and abdominal wall or vaginal wall, along with mild inflammatory reaction from 4 weeks to 12 weeks. Abdominal grafts of Repelvica mid-urethral sling and TVT-O induced comparable tissue reaction (histological score 10.5 versus 10.5 at 4 weeks, 10.0 versus 9.5 at 12 weeks;both P>0.05). Vaginal grafts of Repelvica mid-urethral sling had lower histological score than TVT-O (histological score 6.0 versus 12.0 at 4 weeks, 8.5 versus 12.5 at 12 weeks), however the differences were not statistically significant (both P>0.05).ConclusionsChinese-made Repelvica mid-urethral sling exhibits good histocompatibility. Vaginal graft of Repelvica mid-urethral sling evoks minor tissue reaction, which could be attributed to its lightweighted property and favored its clinical application.

关 键 词：尿失禁 压力性 聚丙烯类 组织相容性 尿道下悬吊术 尿道中段悬吊带 

分 类 号：R711.59[医药卫生—妇产科学] R-332[医药卫生—临床医学]