舒芬太尼注射剂与芬太尼注射剂用于经口气管插管患者镇痛镇静的临床研究  

Clinical study on sufentanil injection and fentanyl citrate injection for analgesic sedation in patients with oral tracheal intubation

作　　者：陈志林[1] 吴念花 张娇娇[1] 郑盼盼 陈棠堡 陈佩莹 郑强 CHEN Zhi-lin;WU Nian-hua;ZHANG Jiao-jiao;ZHENG Pan-pan;CHEN Tang-bao;CHEN Pei-ying;ZHENG Qiang(Intensive Care Unit,The First Affiliated Hospital of Hainan Medical University, Haikou 570102,China)

机构地区：[1]海南医学院第一附属医院重症医学科,海口570102

出　　处：《中国临床药理学杂志》2019年第2期109-111,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察舒芬太尼与芬太尼用于经口气管插管患者镇痛镇静的临床疗效。方法将429例经口气管插管患者随机分为试验组229例和对照组200例。对照组予以芬太尼0. 1μg·kg^(-1)·h^(-1),静脉泵入;试验组予以舒芬太尼0. 1μg·kg^(-1)·h^(-1),静脉泵入。比较2组患者的镇痛镇静效果、用药后30 s,10min,1 h,4 h的呼吸频率、心率、血压的变化情况,以及药物不良反应发生率。结果用药后,试验组和对照组的立即镇痛、镇静有效率分别为98. 67%(226例/229例)与92. 50%(185例/200例),差异有统计学意义(P <0. 05)。试验组用药后呼吸,心率,血压的水平均低于同期对照组,差异均有统计学意义(均P <0. 05);试验组和对照组均出现皮肤瘙痒和呕吐,2组患者的药物不良反应发生率分别为35. 81%(82例/229例)和34. 00%(68例/200例),差异无统计学意义(P> 0. 05)。结论舒芬太尼对经口气管插管患者的镇痛镇静效果优于芬太尼,且安全性高。Objective To observe the clinical efficacy of sufentanil and fentanyl citrate for analgesic sedation in patients with oral tracheal intubation. Methods A total of 429 patients with oral tracheal intubation were randomly divided into treatment group( 229 cases) and control group( 200 cases). The control group was given 0. 1 μg·kg^-1·h^-1 fentanyl citrate through intravenous pump,while the treatment group received 0. 1μg·kg^-1·h^-1 sufentanil. The changes of respiratory rate,heart rate and blood pressure at 30 s,10 min,1 h and 4 h after treatment,and the incidence of adverse drug reactions were compared between the two groups. Results The analgesia/sedation rates of the treatment group and the control group were 98. 67%( 226 cases/229 cases) and 92. 50%( 185 cases/200 cases),respectively,with statistically significant difference( P < 0. 05). The respiration rate,heart rate and blood pressure of the treatment group were significantly lower than those of the control group after treatment( P < 0. 05). The adverse drug reactions of the treatment group and the control group were itching and vomiting,and the incidences of adverse drug events in the two groups were 35. 81%( 82 cases/229 cases) and 34. 00%( 68 cases/200 cases),respectively,with no statistically significant difference( P > 0. 05). Conclusion The sedative and analgesic effects of sufentanil in combaination with dexmedetomidine in patients with oral tracheal intubation is superior to that of fentanyl citrate and has high safety.

关 键 词：舒芬太尼注射剂 右美托咪定注射剂 重症加强护理病房 镇痛镇静 机械通气 

分 类 号：R971[医药卫生—药品]