西沙必利对小儿便秘合并肺部感染患儿炎症因子及免疫水平的影响  

Impact of cisapride on inflammatory factors and immune level of constipation children complicated with pulmonary infection

作　　者：吕聪聪[1] 钟伟娟 何春风[1] 吕建飞[1] 李慧竹[1] LYU Cong-cong;ZHONG Wei-juan;HE Chun-feng;LYU Jian-fei;LI Hui-zhu(Lishui People's Hospital,Lishui,Zhejiang 323000,China)

机构地区：[1]丽水市人民医院儿科

出　　处：《中华医院感染学杂志》2019年第1期142-145,共4页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅医药卫生科技计划基金资助项目(2013KYB174)

摘　　要：目的探讨西沙比利对小儿便秘合并肺部感染患儿炎症因子和免疫水平的影响。方法选择2015年5月-2017年3月医院儿科收治的小儿便秘合并肺部感染患儿120例,随机数字法分为对照组和研究组,每组60例。对照组采用双歧杆菌三联活菌胶囊治疗,研究组在对照组基础上联合西沙比利治疗,采用酶联免疫吸附试验测定两组患儿治疗前后白介素-8(IL-8)、白介素-10(IL-10)及单核细胞核因子(NF-kB)水平;采用流式细胞计数仪测定外周血T淋巴细胞亚群水平,观察两组患儿治疗效果。结果研究组患儿疗效率为95.00%,高于对照组的81.67%,两组比较差异有统计学意义(χ^2=5.175,P=0.023);治疗后两组炎症因子水平均降低(P<0.05);且研究组治疗后降低幅度均优于对照组(P<0.05);研究组与对照组治疗后免疫水平均高于治疗前(P<0.05),且研究组治疗后CD4^+、CD8^+、CD4^+/CD8^+比值升高幅度均优于对照组(P<0.05)。结论西沙比利用于小儿便秘合并肺部感染患儿中优于双歧杆菌三联活菌胶囊,有助于提高临床疗效,降低炎症因子,改善机体免疫水平,值得推广应用。OBJECTIVE To explore the impact of cisapride on inflammatory factors and immune level of constipation children complicated with pulmonary infection.METHODS A total of 120 constipation children complicated with pulmonary infection who were treated in pediatrics department from May 2015 to Mar 2017 were enrolled in the study and randomly divided into the control group and the study group,with 60 cases in each group.The control group was treated with bifidobacterium triple viable capsule,while the study group was given additional cisapride on basis of the treatment of the control group.The levels of interleukin-8(IL-8),interleukin-10(IL-10)and monocyte nuclear factor(NF-kB)of the two groups of children were determined by using enzyme-linked immunosorbent assay before and after the treatment,the levels of peripheral blood T lymphocyte subsets were detected with the use of flow cytometry,and the curative effects were observed.RESULTS The effective rate of treatment of the study group was 95.00%,significantly higher than 81.67% of the control group(χ^2=5.175,P=0.023).The levels of inflammatory factors of the two groups were reduced after the treatment(P<0.05),which were reduced more significantly in the study group than in the control group after the treatment(P<0.05).The immune levels of the study group and the control group were higher after the treatment than before the treatment(P<0.05);the levels of CD4^+,CD8^+and ratio of CD4^+to CD8^+were elevated more significantly in the study group than in the control group after the treatment(P<0.05).CONCLUSION Cisapride is superior to bifidobacterium triple viable capsule in the treatment of constipation children complicated with pulmonary infection,facilitates the improvement of clinical curative effect,reduces the levels of inflammatory factors and improves the immunity.

关 键 词：西沙比利 小儿便秘 肺部感染 临床效果 机体免疫 

分 类 号：R446[医药卫生—诊断学]