益气养阴、固表利咽法治疗气阴两虚型IgA肾病临床研究  

Clinical Study of Methods of Replenishing Qi, Nourishing Yin, Consolidating the Exterior and Relieving the Sore Throat on IgA Nephropathy with Qi and Yin Deficiency Syndrome

作　　者：吴飞翔 吴君平 吴晋兰 WU Feixiang;WU Junping;WU Jinlan

机构地区：[1]杭州市余杭区中西医结合医院,浙江杭州311100

出　　处：《新中医》2019年第1期115-118,共4页New Chinese Medicine

基　　金：浙江省中医药重点学科建设项目(2017-XK-D02)

摘　　要：目的:观察益气养阴、固表利咽法治疗气阴两虚型IgA肾病的临床疗效。方法:将IgA肾病60例随机分为试验组与对照组,每组30例;2组患者均予以西医常规治疗,试验组在此基础上加用益气养阴、固表利咽为主的中药治疗;疗程均为6月,记录所有受试者治疗前、治疗后2月、4月、6月时中医证候积分、感冒次数及安全性指标,并评价总体临床疗效。结果:总有效率试验组为86.7%,对照组为66.7%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组在半年内的治疗后感冒次数均比治疗前减少(P <0.05),且试验组感冒次数明显少于对照组(P <0.05)。治疗后,2组腰膝酸软、神疲乏力、面色少华、咽干、发热恶寒等中医证候积分均较治疗前明显下降(P <0.05),且试验组上述各项积分下降较对照组更显著(P <0.05)。治疗后2月、4月、6月,2组中医证候总积分均较治疗前明显降低(P <0.05),且试验组总积分下降较对照组同时间段更显著(P <0.05)。2组患者治疗前后肝功能、血常规、大便常规、心电图均无明显变化。结论:益气养阴、固表利咽法可以明显改善IgA肾病患者的相关临床症状及体征,减少患者的感冒次数,值得临床推广应用。Objective: To observe the clinical effect of methods of replenishing qi, nourishing yin, consolidating the exterior and relieving the sore throat on IgA nephropathy with qi and yin deficiency syndrome. Methods:Divided 60 cases ofIgA nephropathy randomly into the experiment group and the control group,30 cases in each group. The two groups were both given routine western medicine,while the experiment group was additionally treated with Chinese medicine treatment mainly for replenishing qi,nourishing yin,consolidating the exterior and relieving the sore throat. The course of the treatment was 6 months. Recorded Chinese medicine syndrome scores,times of catching cold and safety indexes of all subjects before treatment and 2 months,4 months,and 6 months after treatment,and evaluated the overall clinical effect. Results:The total effective rate was 86.7% in the experiment group and 66.7% in the control group,difference being significant(P < 0.05).After treatment,the times of catching cold after treatment within half a year in the two groups were lower than those before treatment(P < 0.05);the times of catching cold in the experiment group were significantly lower than those in the control group(P < 0.05). After treatment,the scores of such Chinese medicine syndromes as soreness and weakness of waist and knees, fatigue, lusterless complexion, dry throat and fever with cold aversion were evidently lower than those before treatment(P < 0.05);these scores in the experiment group were decreased more obviously than those in the control group(P < 0.05). 2 months,4 months,and 6 months after treatment,the total scores of Chinese medicine syndromes in the two groups were clearly lower than those before treatment(P < 0.05);the decrease of the total scores in the experiment group was more clearly than that in the control group at the same time point(P < 0.05). There were no significant changes being found in the liver function,blood routine,stool routine,and electrocardiogram in the two groups before and after treatment.Conclusio

关 键 词：IGA肾病 中西医结合疗法 气阴两虚 益气养阴 固表利咽 

分 类 号：R692.3[医药卫生—泌尿科学]