基于多指标权重分析和均匀设计法优选麦冬提取工艺  

Extraction Process Optimization of Ophiopogon Based on Multi-index Weight Analysis and Uniform Design

作　　者：李颖 朱志军[1] 李莹丽[1] 杜伟霞 王永祥 Li Ying;Zhu Zhijun;Li Yingli;Du Weixia;Wang Yongxiang(College of Pharmacy,Henan University of Chinese Medicine, Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《中国药师》2019年第1期44-47,共4页China Pharmacist

基　　金：河南省科技攻关计划(编号:162102310450)

摘　　要：目的:优选麦冬提取工艺。方法:以麦冬皂苷D﹑麦冬总皂苷含量和浸膏得率为评价指标,采用层次分析法(AHP)﹑CRITIC法以及AHP-CRITIC混合加权法确定权重,均匀设计试验优化提取工艺。结果:最佳提取工艺为:12倍71%乙醇,回流提取2次,每次0. 5 h。结论:AHP-CRITIC混合加权法真实客观,重复性好,表明优化得到的最佳提取工艺合理稳定,切实可行。为生脉分散片的生产工艺优化提供科学基础。Objective: To optimize the extraction process of Ophiopogon japonicus. Methods: With the content of Ophiopogon saponin D,the total saponin content of Ophiopogon japonicus and the extract yield as the evaluation indices,the weights were determined by analytic hierarchy process( AHP), criteria importance through intercriteria correlation( CRITIC) and AHP-CRITIC combined with weighting method and the uniform design experiment to optimize the extraction process. Results: The optimum extraction technology conditions were as follows: adding 12-fold amount of 71% ethanol and reflux extracting 3 times with0. 5h for each time. Conclusion: AHP-CRITIC combined with weighting method is objective and reproducible,indicating that the optimal extraction process is reasonable, stable and feasible, which provides scientific basis for the production process optimization of Shengmai dispersible tablets.

关 键 词：麦冬 均匀设计试验 权重分析 提取工艺 AHP-CRITIC混合加权法 

分 类 号：R284.2[医药卫生—中药学]