Gram-scale preparation of dialkylideneacetones through Ca(OH)_2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH  

作　　者：Hao Zhang Mengting Han Chenggen Yang Lei Yu Qing Xu 

机构地区：[1]Guangling College, Yangzhou University [2]School of Chemistry and Chemical Engineering, Yangzhou University

出　　处：《Chinese Chemical Letters》2019年第1期263-265,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 21202141, 21672163);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP);the high level talent support project of Yangzhou University (top-notch talent, L. Yu);Yangzhou Natural Science Foundation (No. YZ2014040);the Natural Science Foundation of Guangling College (No. ZKZD17005) for financial support

摘　　要：A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)_2 as the cheap, mild base catalyst and dilute aqueous EtOH(20%, v/v)as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level.A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)_2 as the cheap, mild base catalyst and dilute aqueous EtOH(20%, v/v)as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level.

关 键 词：Claisen-Schmidt condensation ACETONE ALDEHYDE α β-Unsaturated KETONE Dialkylideneacetone 

分 类 号：O6[理学—化学]