罗汉果苷ⅢE对心肌纤维化的保护作用  

Protective effect of Mogroside ⅢE on myocardial fibrosis

作　　者：石亚男 刘巍 Shi Yanan;Liu Wei(Four Wards of Cardiovascular Internal Medicine,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院心血管内科四病房,150001

出　　处：《国际免疫学杂志》2019年第1期87-90,共4页International Journal of Immunology

基　　金：国家自然科学基金(81270310);哈尔滨医科大学于维汉院士杰出青年基金(301000100005);黑龙江省教育厅海外学人重点项目(1252HQ013).

摘　　要：心肌纤维化不仅是诱发多种心血管疾病的重要病因,也是多种心血管疾病进展至终末期的共同病理表现。Toll样受体4(toll like receptor 4,TLR4)是介导心肌炎症并导致心肌纤维化的重要信号分子,其与配体结合后可通过MyD88-MAPK信号通路诱导致纤维化因子的激活与释放,从而导致纤维化的发生发展。罗汉果苷ⅢE(mogrosideⅢE,MGⅢE)通过调节TLR4相关信号通路可抑制炎症介质及致纤维化因子的激活与释放,从而抑制心肌纤维化的进展。Myocardial fibrosis is not only an important factor of inducing cardiovascular diseases but also a common pathological manifestations of the end-stage of various heart diseases.Toll like receptor 4(TLR4)is a vital signal molecule mediating inflammatory reaction in myocardium to trigger myocardial fibrosis.TLR4 can induce the activation and release of fibrogenic factors to contribute to fibrosis through MyD88-MAPK signaling pathway after binding with its ligand.MogrosideⅢE can inhibit the activation and release of inflammatory mediators and fibrogenic factors through regulating TLR4/MyD88-MAPK signaling pathway,and then inhibiting the progression of myocardial fibrosis.

关 键 词：心肌纤维化 TOLL样受体4 罗汉果苷ⅢE 

分 类 号：R542.23[医药卫生—心血管疾病]