甲强龙与复方磺胺甲噁唑联用对中重度缺氧艾滋病患者伴肺孢子菌肺炎的临床疗效评价  

Efficacy of Methylprednisolone Combined with Compound Sulfamethox-azole in Excessie Hypoxic AIDS Patients with Pneumocystis Pneumonia

作　　者：尹海滨 廖晓庆 曾宪蓝[1] 熊洪海 宋伟 YING Hai-bing;LIAO Xiao-qing;ZENG Xian-lan;XIONG Hong-hai;SONG Wei(The Central People's Hospital of Ji'an,Ji'an Jiangxi 343000,China;Hospital Affiliated to Jinggangshan University,Ji'an Jiangxi 343000,China)

机构地区：[1]吉安市中心人民医院,江西吉安343000 [2]井冈山大学附属医院,江西吉安343000

出　　处：《抗感染药学》2018年第12期2042-2045,共4页Anti-infection Pharmacy

基　　金：吉安市科技基金项目(编号:2018-06号)

摘　　要：目的:探究甲强龙与复方磺胺甲噁唑对中重度缺氧艾滋病患者伴肺孢子菌肺炎的临床疗效及其对动脉血氧分压(PaO_2)、末梢血氧饱和度(SpO_2)的影响。方法:选取2015年1月—2018年8月间收治的中重度缺氧艾滋病患者伴肺孢子菌肺炎患者60例资料,按其治疗方法的不同将其分为对照组和观察组,每组30例;对照组患者给予复方磺胺甲噁唑治疗,观察组患者给予甲强龙与复方磺胺甲噁唑治疗,比较两组患者治疗后的总有效率、呼吸困难及肺部病变改善率差异,以及治疗不同时段后PaO_2、SpO_2水平测得值的变化情况。结果:治疗7 d后,观察组患者PaO_2、SpO_2和呼吸困难改善率优于对照组(P<0.05);而肺部病变改善率两组间经组间比较其差异无统计学意义(P>0.05);治疗21 d后肺部病变改善率优于对照组(P<0.05);观察组患者PaO_2、SpO_2和呼吸困难及肺部病变的改善率均优于对照组(P<0.05)。结论:采用甲强龙与复方磺胺甲噁唑治疗中重度缺氧艾滋病伴肺孢子菌肺炎患者的疗效较为确切,有效改善了其PaO_2、SpO_2水平和呼吸困难状况,提高了患者的生活质量。Objective:To evaluate the clinical efficacy of methylprednisolone combined with compound sulfa-methoxazole in moderate and severe hypoxic AIDS with pneumocystis pneumonia and its influence on arterial partialoxygen pressure(PaO2) and peripheral oxygen saturation(SpO2). Methods:60 cases of AIDS complicated with Pneu-mocystis jeroveci pneumonia from January 2015 to January 2018 in our hospital were selected. Based on their differenttreatment methods, they were divided into two groups:the control group(n=30 cases) and the observation group(n=30 cases). The control group was treated with compound sulfamethoxazole, and the observation group was treated withmethylprednisolone combined with sulfamethoxazole. The efficacies of two treatments were compared in total efficientrate. Results:There was no significant difference in PaO2, SpO2, dyspnea and pulmonary lesions between the twogroups before treatment(P>0.05). After 7 days of treatment, the PaO2, SpO2 and dyspnea in the observation group wereimproved compared with those in the control group(P<0.05), but there was no significant difference in lung conditionbetween the two groups(P>0.05). After 21 days of treatment, the lung lesions were significantly improved comparedwith those in the control group(P<0.05). After 3 weeks of treatment, the PaO2, SpO2, dyspnea and pulmonary lesions inthe observation group were significantly improved compared with those in the control group(P<0.05). Conclusion:Theefficacy of methylprednisolone and compound sulfamethoxazole in the treatment of moderate and severe hypoxic AIDSpatients with pneumocystis pneumoniae is relatively accurate, effectively improving the level of PaO2, SpO2 and respira-tory difficulties, so as to improve the in whole.

关 键 词：甲强龙 复方磺胺甲噁唑 艾滋病 肺孢子菌肺炎 

分 类 号：R969.3[医药卫生—药理学]