基于硼酸修饰的多壁碳纳米管的QCM血糖传感器的研究  

Study on QCM blood sugar sensor based on boric acid modified multi-walled carbon

作　　者：张振晓 窦倩 王娇娜[1] 李从举[1] 戴庆[2] Zhang Zhenxiao;Dou Qian;Wang Jiaona;Li Congju;Dai Qing(College of Material Science and Engineering,Beijing Institute of Fashion Technology, Beijing Key Laboratory of Clothing Materials R&D and Assessment,Beijing 100029;National Center for Nanoseience and Technology,Beijing 100190)

机构地区：[1]北京服装学院材料科学与工程学院北京市服装材料研究开发与评价重点实验室,北京100029 [2]国家纳米科学中心,北京100190

出　　处：《化工新型材料》2019年第1期202-205,210,共5页New Chemical Materials

基　　金：国家自然科学基金(51503005);北京市科技北京百名领军人才工程(Z16111000490000);北京市教育委员会科技计划一般项目(SQKM201710012004)

摘　　要：糖尿病是一种严重威胁人体健康且无法治愈的疾病。然而,目前缺乏稳定性好、成本低的血糖检测方法,设计并制备了一种新型的基于石英晶体微天平(QCM)的血糖检测技术,选择氨基苯硼酸作为葡萄糖的识别单元,将氨基苯硼酸与氧化多壁碳纳米管(MWCNTs)结合,然后再涂覆至金电极上。利用QCM检测薄膜与葡萄糖的结合特性。结果表明:该薄膜能够检测生理条件下(pH=7.0～7.5)的葡萄糖浓度变化,整个检测范围为1.1～33.3mmol/L,且具有良好的可再生性,并对其他干扰糖(果糖、麦芽糖、核糖、乳糖、木糖、蔗糖、半乳糖、甘露糖)有较好的选择性。这项工作为检测血糖提供了一种新方法。Diabetes is a serious threat to human health,and cannot be cured.However,there is a lack of stable and low cost blood glucose detection system.A new QCM blood glucose detection system was designed and prepared.Aminophenylboronic acid was chose as recognition unit for detect glucose.Then aminophenylboronic acid was combined with the oxidized multiwall carbon tube and finally coated on the quartz crystal plate.Then QCM was used to detect the binding properties of membrane to glucose.The results showed that the film could detect the change of glucose concentration under physiological conditions(pH=7.0~7.5).The whole detection range was from 1.1~33.3 mmol/L.It also had good reproducibility and excellent selectivity to other interfering sugars(fructose,maltose,ribose,lactose,xylose,sucrose,galactose and mannose).This work provided a new method for continuous measurement of blood glucose.

关 键 词：苯硼酸 多壁碳纳米管 葡萄糖 QCM传感器 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TB383.1[自动化与计算机技术—控制科学与工程]