仿生介孔二氧化硅用于高效液相色谱拆分手性化合物  

Biomimetic Mesoporous Silica for High Performance Liquid Chromatography Resolution of Chiral Compounds

作　　者：吕云 付仕国 田春容 袁宝燕 段爱红[1] 袁黎明[1] Lv Yun;Fu Shiguo;Tian Chunrong;Yuan Baoyan;Duan Aihong;Yuan Liming(Faculty of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500)

机构地区：[1]云南师范大学化学化工学院,昆明650500

出　　处：《化学通报》2019年第2期175-178,共4页Chemistry

基　　金：国家自然科学基金项目(21665028)资助

摘　　要：仿生介孔硅是以有机物作为模板,可有效复刻模板的独特形貌,从而得到其相同或相似结构孔径的介孔硅。本文从仿生的观点出发,从蟹壳中提取得到几丁质膜,将其用作模板制备了仿生手性向列型介孔二氧化硅,并用其制备了液相色谱柱,进行了手性化合物拆分实验。结果表明,该色谱固定相对10个手性化合物有一定的手性分离效果。The biomimetic mesoporous silica is a mesoporous silica,which using organic silicane as a template that can effectively reproduce the unique morphology of the template, thereby obtaining the same or similar mesoporous structure with mesoporous silica. In this paper, bionic mesoporous silica was prepared from the biomimetic point of view,and the bionic chiral nematic mesoporous silica was prepared by extracted the chitin film from the crab shell as a template,and then the bionic chiral nematic mesoporous silica was used to prepare liquid chromatography column. The prepared column was used for the separation of chiral compounds in the high performance liquid chromatograph. The experimental results showed that the chromatographic stationary phase has a certain chiral separation effect to 10 chiral compounds.

关 键 词：仿生介孔二氧化硅 高效液相色谱 手性固定相 手性分离 

分 类 号：O652.6[理学—分析化学]