基于壳聚糖衍生物的Al^(3+)荧光探针的设计合成  

Design and Synthesis of Al^(3+)-Selective Fluorescent Probe Based on Chitosan Derivative

作　　者：林锦斌 徐宏达 叶伟 傅琼瑶 陈瑞 曾莉芳 张军 LIN Jin-bin;XU Hong-da;YE Wei;FU Qiong-yao;CHEN Rui;ZENG Li-fang;ZHANG Jun(Laboratory of Environment Monitoring,School of Tropical and Laboratory Medicine,Hainan Medical University,Haikou 571199,China;School of International Education,Hainan Medical University,Haikou 571199,China)

机构地区：[1]海南医学院热带医学与检验医学院环境监测实验室,海南海口571199 [2]海南医学院国际教育学院,海南海口571199

出　　处：《化学试剂》2019年第2期182-185,共4页Chemical Reagents

基　　金：国家自然科学基金资助项目(81560347;81660356);大学生创新性课题项目(2017099);海南省重点研发项目(ZDYF2017103)

摘　　要：人体摄入过量的Al^(3+)会导致多种疾病,因此Al^(3+)的检测具有重要的意义。荧光探针法在目标物质检测中具有选择性好、灵敏度高等优点,已成为重要的检测手段。以2-羟基-1-萘甲醛和羧甲基壳聚糖为原料,在乙醇溶液中回流反应8 h,高产率得到一种高选择性Al^(3+)荧光探针。在常见的金属离子和阴离子中,该荧光探针对Al^(3+)呈现出较好的选择性和较高的灵敏度。在V(乙醇)∶V(水)=4∶1、p H 6. 0、50 mmol/L羟乙基哌嗪乙硫磺酸(HEPES)溶液中,该探针对Al^(3+)的线性响应范围为4. 0×10-5～1. 0×10-4mol/L,检出限为1. 3×10-5mol/L。Overtake of Al^3+causes various diseases.Thus,the detection of Al^3+is of great importance.Among the detection methods,fluorescent probe method has many advantages,such as good selectivity and high sensitivity.Al3+-Selective fluorescent probe was synthesized using 2-hydroxy-1-naphthaldehydes and carboxymethyl chitosan as raw materials.Probe P showed good selectivity to Al^3+compared to other tested metal ions and anions.The proposed probe showed a wide linear range of 4. 0× 10^-5~ 1. 0× 10^-4 mol/L with detection limit of 1. 3×10^-5 mol/L in water-ethanol solution( V( ethanol) ∶V( water) = 4 ∶1,p H 6. 0,50 mmol/L N-2-hydroxyethylpiperazine-N-ethane-sulphonicacid( HEPES) solution).

关 键 词：壳聚糖 荧光探针 AL^3+ 

分 类 号：O022.7[理学]