服药训练策略对HIV/AIDS病人抗病毒治疗48周内服药依从性的影响  

Effect of medication training strategy on drug compliance of HIV/AIDS patients with antiretroviral therapy within 48 weeks

作　　者：宋晓璟[1] 李雁凌[1] 吕玮[1] 韩扬[1] 王焕玲[1] 刘正印[1] 曹玮[1] 赵霞[1] 李太生[1] SONG Xiaojing;LI Yanling;L YU Wei;HAN Yang;WANG Huanling;LIU Zhengyin;CAO Wei;ZHAO Xia;LI Taisheng(Department of Infectious Diseases,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院感染内科,北京100730

出　　处：《中国艾滋病性病》2019年第1期5-8,共4页Chinese Journal of Aids & STD

基　　金：国家"十三五"科技重大专项项目(2017ZX10202101);中国医学科学院医学与健康科技创新工程项目(2017-12M-1-014)~~

摘　　要：目的评估服药训练策略对中国艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)抗病毒治疗(ART)0～48周服药依从性的影响。方法纳入北京协和医院艾滋病门诊2013—2014年进行初次ART的HIV/AIDS病人90例,按照就诊时间分为干预组和对照组。干预组采用服药训练策略进行干预,对照组采用常规健康教育,评价治疗期间两组病人服药依从性和病毒抑制情况。结果在干预12、24和48周时,干预组完全依从的病人占比达到97.73%、93.18%和95.45%,而对照组仅有58.14%、44.19%、72.09%的病人能够达到完全依从,差异有统计学意义(P<0.05)。干预12、24和48周时,干预组的服药依从率分别为99.93%,99.81%和99.88%,均明显高于对照组98.84%,98.31%和99.33%,差异有统计学意义(P<0.05)。干预48周时干预组病人病毒抑制率97.73%,对照组为81.40%,两者差异有统计学意义(P<0.05)。结论服药训练策略能够提高初始治疗HIV/AIDS病人48周内的服药依从性,从而进一步提高ART病毒抑制率。Objective To evaluate the effect of medication training strategy on the compliance of antiviral therapy(ART)for HIV/AIDS patients in China for 0 to 48 weeks.Methods Ninety HIV/AIDS patients receiving initial ART in the AIDS clinic of Peking union medical college hospital from 2013 to 2014were divided into the intervention group and control group according to the treatment time.The intervention group was treated with medication training strategy,while the control group was treated with routine health education,and the medication compliance and virus suppression of the two groups during treatment were evaluated.Results At the 12th,24th and 48th week of the intervention,97.73%,93.18% and 95.45% of patients in the intervention group were fully compliant,while only 58.14%,44.19% and 72.09%of patients in the control group were fully compliant,with a statistically significant difference(P<0.05).At the 12 th,24th and 48 th week of the intervention,the compliance rates of the intervention group were 99.93%,99.81% and 99.88% respectively,which were significantly higher than those of the control group 98.84%,98.31% and 99.33%(P<0.05).The difference was statistically significant(P<0.05).After 48 weeks of intervention,the virus inhibition rate in the intervention group was 97.73%,compared with81.40%in the control group,and the difference was statistically significant(P<0.05).Conclusion The medication training strategy can improve the medication compliance of HIV/AIDS patients within 48 weeks of initial treatment,thus further improve virus inhibition rate in ART.

关 键 词：艾滋病 抗病毒治疗 服药依从性 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]