中西药联合改善子宫内膜容受性临床试验的meta分析  

Combined Chinese and western medicine for endometrial receptivity: A meta analysis of clinical trials

作　　者：江媚[1] 马丽然[1] 康佳[1] Jiang Mei;Ma Liran;Kang Jia(Department of Gynaecology,Beijing Gulou Traditional Chinese Medicine Hospital,Beijing 100009,China)

机构地区：[1]北京市鼓楼中医医院妇科,100009

出　　处：《国际中医中药杂志》2019年第2期210-212,F0003,共4页International Journal of Traditional Chinese Medicine

基　　金：北京中医药薪火传承“3+3”工程基层老中医传承工作室建设项目(2018年);东城区康佳知名中医工作室(2016年);北京中医药科技发展资金项目(QN2015-02).

摘　　要：目的系统评价中西药联合改善子宫内膜容受性的疗效。方法计算机检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、PubMed数据库、Cochrane Library、EMBASE各库建库至2018年3月有关中药联合西药与西药治疗对照改善子宫内膜容受性的临床RCT,采用RevMan 5.3软件对所收集的数据进行meta分析。结果共纳入7篇文献,受试者499例。Meta分析结果显示,中西药联合治疗在提高患者临床妊娠率[RR=1.78,95% CI(1.41~2.26)]、增加患者的子宫内膜厚度[MD=1.42,95% CI(1.27~1.58)]、提高患者A型子宫内膜所占比例[RR=1.25,95% CI(1.07~1.45)]、降低患者子宫内膜血流搏动指数[SMD=-1.41,95% CI(-2.18^-0.64)]等方面优于单纯西药治疗,在降低子宫内膜血流阻力指数[SMD=-1.11,95% CI(-2.52~0.30)]方面差异无统计学意义。结论 中西药联合改善子宫内膜容受性有一定优势,但该结论尚需更多高质量研究予以验证。Objective To systemically evaluate the effects of combined Chinese and western medicine in improving endometrial receptivity. Methods A search for relevant articles ran on the CNKI, WanFang, VIP, PubMed, EMBASE and Cochrane library. The randomized controlled trails of combined Chinese and western medicine therapy versus western medicine alone for improving endometrial receptivity were retieved The Revman 5.3 software was used for Meta-analysis according to Cochrane system evaluation method. Results A total of 7 randomized controlled trails involving 499 patients were included. There was statistically significant difference in the growth of clinical pregnancy rate [RR=1.78, 95% CI (1.41, 2.26)], the increase of patients with endometrial thickness [MD=1.42, 95% CI(1.27, 1.58)], the raise of the proportion with type A endometrium [RR=1.25, 95% CI (1.07, 1.45)], the reduction of the patients with endometrial PI [SMD=-1.41, 95% CI (-2.18, -0.64)]. There was no statistically significant difference in the reduction of endometrial RI [SMD=-1.11, 95% CI (-2.52,0.30)]. Conclusions The therapy integrated Chinese and western medicine for endometrial receptivity is better than simple western medicine. But there is less literature on the high quality, suggesting that the methodology of clinical research should be further improved in the future.

关 键 词：中西医结合疗法 子宫内膜容受性 体外受精 胚胎移植 META分析 系统评价 

分 类 号：R714.8[医药卫生—妇产科学]