老年急性冠脉综合征患者血清sLOX-1和BIL水平分析  

Analysis of serum sLOX-1 and BIL levels in elderly patients with acute coronary syndrome

作　　者：孙晓琪[1] 陈红光 胡馨予[1] 张赢予[1] SUN Xiao-qi;CHEN Hong-guang;HU Xin-yu;ZHANG Ying-yu(School of Clinical Medicine ,Colleges of Changchun Medical College ,Changchun 130021,P.R.China;Department of Cardiology ,the Second Affiliated Hospital of Shenyang Medical College, Shenyang 110035,P.R.China)

机构地区：[1]长春医学高等专科学校临床医学院,吉林长春130021 [2]沈阳医学院附属第二医院心血管二科,辽宁沈阳110035

出　　处：《社区医学杂志》2018年第18期1427-1430,共4页Journal Of Community Medicine

摘　　要：目的目前我国老年急性冠脉综合征(acute coronary sydrome,ACS)患者发病率逐年递增,严重威胁了老年人的身体健康,如何及早诊治ACS患者尤为关键。本研究分析血清人可溶性凝集样素氧化型低密度脂蛋白受体1(human soluble lectin-like oxidized low density lipoprotein receptor-1,sLOX-1)与胆红素(bilirubin,BIL)在老年急性冠脉综合征(acute coronary sydrome,ACS)患者中的临床检测意义。方法收集2017-01-04-2017-12-04在沈阳医学院附属第二医院心血管二科接受诊断治疗的38例ACS老年患者的临床资料作为研究组。另外选取同期健康体检的38例老年健康者作为对照组。比较两组基线资料、血液学指标、血清sLOX-1及BIL水平。采用相关性分析探讨老年ACS患者血清sLOX-1与BIL的关系。比较不同病变支数患者血清sLOX-1与BIL的表达水平。结果观察组C反应蛋白(C reactive protein,CRP)水平为(12.26±5.28)mg/L,明显高于对照组的(2.17±1.12)mg/L,t=11.52,P<0.001;高密度脂蛋白(high density lipoprotein,HDL)水平为(0.98±0.16)mmol/L,明显低于对照组的(1.31±0.12)mmol/L,t=10.17,P<0.001。观察组血清sLOX-1水平为(4.09±2.91)mg/L,明显高于对照组的(1.88±1.45)mg/L,t=4.190,P<0.001;间接胆红素(indirect bilirubin,IBIL)水平为(6.22±2.84)mmol/L,明显低于对照组的(8.53±3.17)mmol/L,t=3.346,P<0.001;直接胆红素(direct bilirubin,DBIL)水平为(2.64±0.82)mmol/L,明显低于对照组的(3.31±1.83)mmol/L,t=2.060,P=0.043;总胆红素(total bilirubin,TBIL)水平为(8.67±3.92)mmol/L,明显低于对照组的(12.06±4.11)mmol/L,t=3.679,P<0.001。老年ACS患者的血清sLOX-1与BIL存在负相关性,r=-0.402,P=0.003。老年ACS患者冠脉病变支数越多,血清sLOX-1水平越高,F=3.503,P=0.041,而TBIL水平逐渐降低,F=0.434,P=0.651。结论老年ACS患者体内血清sLOX-1水平明显上升,BIL水平明显降低,且老年ACS患者的冠脉病变支数与血清sLOX-1及BIL水平密切相关。OBJECTIVE At present,the incidence of acute coronary syndrome(ACS)in elderly patients is increasing year by year,which seriously threatens the health of the elderly.How to diagnose and treat ACS patients as soon as possible is particularly important.This study aims to analyze the clinical significance of serum human soluble lectin-like oxidized low density lipoprotein receptor-1(sLOX-1)and bilirubin(BIL)in elderly patients with ACS.METHODS Clinical data of38 elderly patients with ACS received treatment in the Second Affiliated Hospital of Shenyang Medical College from January 4,2017 to December 4,2017 were retrospectively analyzed.38 healthy elderly persons at the same time in the same hospital were chosen as the control group.The general information,the hematological indexes,the levels of sLOX-1and BIL in two groups were compared.The correlation between the serum sLOX-1and BIL in the elderly patients with ACS was analyzed.The levels of sLOX-1and BIL were compared in different lesions groups.RESULTS The C reactive protein level in observe group was(12.26±5.28)mg/L,obviously higher than that in control group(2.17±1.12)mg/L,t=11.52,P<0.001.The high density lipoprotein level in observe group(0.98±0.16)mmol/L was obviously lower than that in control group(1.31±0.12)mmol/L,t=10.17,P<0.001.The serum sLOX-1level in observe group(4.09±2.91)mg/L was obviously higher than that in control group(1.88±1.45)mg/L,t=4.190,P<0.001,and the levels of IBIL(6.22±2.84)mmol/L,DBIL(2.64±0.82)mmol/L,TBIL(8.67±3.92)mmol/L in observe group were obviously lower than those in control group(8.53±3.17)mmol/L,t=3.346,P=0.001;(3.31±1.83)mmol/L,t=2.060,P=0.043;(12.06±4.11)mmol/L,t=3.679,P<0.001.The serum sLOX-1in the elderly patients with ACS had negative correlation with BIL(r=-0.402,P=0.003).The serum sLOX-1was increasing(F=3.503,P=0.041)and the TBIL level was decreasing(F=0.434,P=0.651)as the lesions were increasing.CONCLUSION The sLOX-1level is increasing and the BIL level is decreasing in gerontism ACS.The coronary lesions of ger

关 键 词：急性冠脉综合征 胆红素 人可溶性凝集样素氧化型低密度脂蛋白受体1 老年 

分 类 号：R541.4[医药卫生—心血管疾病]