雷公藤联合UVB治疗急性泛发性扁平苔藓一例  

A case of acute generalized lichen planus treated with tripterygium glycosides combined with UVB

作　　者：刘腾[1] 刘文斌[1] 杨秀敏[1] 魏爱华[1] LIU Teng;LIU Wen-bin;YANG Xiu-min(Department of Dermatology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院皮肤科,北京100730

出　　处：《实用皮肤病学杂志》2018年第6期369-370,373,共3页Journal of Practical Dermatology

摘　　要：42岁女性患者,全身斑丘疹、水疱伴瘙痒2周。躯干、四肢及足背部皮肤弥漫大量暗紫红色、多角形斑丘疹及斑片,表面蜡样光泽,足背部皮肤散在十余处米粒至黄豆大小水疱,尼氏征阴性。皮损组织病理示:表皮角化过度伴角化不全,轻度海绵水肿,基底细胞液化变性;真皮浅层可见以淋巴细胞为主的带状浸润以及较多噬色素细胞,偶见胶样小体。诊断:急性泛发性扁平苔藓。予以抗组胺药、雷公藤多苷片口服,外用糖皮质激素软膏,联合窄谱中波紫外线(UVB)照射治疗3周,皮损渐消退,残存色素沉着斑。随访9个月无复发。A middle-aged woman presented with maculopapule and vesicles over the whole body for 2 weeks, who was healthy and had no special reasons before the rashes developed. A biopsy of the abdominal lesion was performed and showed hyperkeratosis and parakeratosis, mild spongiosis and liquefaction degeneration of basal cells with band infiltration of lymphocytes in superficial dermis. According to the clinical manifestation and the pathology findings, the patient was diagnosed as acute generalized lichen planus. Combined treatment of oral antihistamine drugs and tripterygium glycosides external glucocorticoid and narrowband UVB was given. The rashes receded after 3 weeks of the treatment and there was no recurrence during the follow-up for 9 months.

关 键 词：扁平苔藓 雷公藤多苷 窄谱中波紫外线 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]