2012-2017年武汉市HIV抗体确证检测结果分析  

Analysis on the results of HIV antibody confirmatory in Wuhan from 2012 to 2017

作　　者：刘盼 孔雯骅[1] 唐力[1] 朱泽荣[1] 占建波[2] 王夏[1] 肖鹏[1] 许骏[1] 罗莉[1] 刘满清[1] LIU Pan;KONG Wen-hua;TANG Li;ZHU Ze-rong;ZHAN Jian-bo;WANG Xia;XIAO Peng;XU Jun;LUO Li;LIU Man-qing(Wuhan Center for Diseases Prevention ond Control,Wuhon,Hubei 430015,China)

机构地区：[1]武汉市疾病预防控制中心,湖北武汉430015 [2]湖北省疾病预防控制中心,湖北武汉430079

出　　处：《现代预防医学》2019年第4期728-730,742,共4页Modern Preventive Medicine

基　　金：武汉市卫生计生委科研计划资助项目(WG17Z04)

摘　　要：目的对2012-2017年武汉市HIV初筛阳性样本的检测结果进行分析,了解武汉市HIV抗体确证情况。方法依据《全国艾滋病检测技术规范(2009年版、2015年修订版)》对各筛查机构HIV筛查阳性反应的样本进行酶联免疫复核和免疫印迹确证试验。结果 2012-2017年武汉市艾滋病确证实验室共收到11 749份初筛阳性样本,经复核和确证试验,7 433份(63.26%)诊断为HIV-1抗体阳性,3 780份(32.17%)为HIV-1抗体阴性,536份(4.56%)为HIV-1抗体不确定。阳性病例最多的年龄段为16～30岁。536例不确定样本中有156例(30.41%)进行了随访,120例(76.92%)确证为阳性,13例(8.33%)确证为阴性,23例(14.74%)仍为不确定。结论 2012-2017年武汉市HIV-1抗体阳性数增长趋势明显,应进一步加强急性期和不确定结果病人的管理,做到早发现、早治疗。Objective To understand the consequence of HIV antibody confirmatory testing among the suspected HIV positive samples collected in Wuhan from 2012 to 2017. Methods According to the National Guideline for Detection of HIV/AIDS in China(2009 and 2015), the HIV suspected samples were screened by two fourth-generation HIV enzyme immunoassays for HIV p24 antigen and antibodies to HIV-1 and HIV-2, and specimens with at least one reactive result were further confirmed with HIV-1/2 BLOT 2.2 WB kit. Results A total of 11749 specimens were collected from 2012 to 2017, of which 7433(63.26%) were confirmed to be HIV-1 antibody reactive, 3780(32.17%) were non-reactive and 536(4.56%) were indeterminate. As the sample number kept increasing during study period, the numbers of reactive samples in each year were stably increasing, yet the detection rates for HIV-Ab decreased. Among 536 subjects with HIV indeterminate results, only156(30.41%) were followed up with HIV detection, of which 120(76.92%) converted to be HIV-1 antibody positive, 13(8.33%) were non-reactive and 23(14.74%) remained to be HIV-1 indeterminate. Conclusion The number of HIV-infected cases in Wuhan was increasing in recent years. Specifically, a large number of acute HIV infections shown as HIV-1 antibody non-reactive or indeterminate were found, which requires further attention in the future.

关 键 词：HIV抗体 确证试验 武汉 

分 类 号：R183[医药卫生—流行病学]