奥美拉唑对婴儿上消化道出血血清炎症因子及免疫功能影响  

Omeprazole has an effect on serum inflammatory factors and immune function in infants with gastrointestinal bleeding

作　　者：吴祥[1] 朱冬菊[2] WU Xiang;ZHU Dong ju(Central Hospital of Panzhihua,Panzhihua Sichuan 617067,China)

机构地区：[1]攀枝花市中心医院儿科,攀枝花617067 [2]攀枝花学院临床医学院

出　　处：《中国急救复苏与灾害医学杂志》2019年第2期145-147,共3页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的分析婴儿上消化道出血应用奥美拉唑对其血清炎症因子及免疫功能影响情况。方法选取120例上消化道出血婴儿,采用随机数字法分为对照组和观察组,每组60例。对照组在常规治疗基础上给予西咪替丁5 mg/kg,2次,d,治疗在常规治疗的基础上给予奥美拉唑1 mg/(次·kg)静脉注射,2次,d,连用5 d。观察并比较2组患儿用药后疗效、炎性指标及免疫指标水平。结果观察组有总有效率高于对照组(P<0.01)。2组患儿治疗前IL-2、IL-6、TNF-α的含量比较差异均无统计学意义(P>0.05):治疗后观察组IL-2上升幅度,IL-6、TNF-α下降幅度均比对照组明显(P<0.05)。2组患儿治疗前CD4^+、CD8^+细胞含量比较差异元统计学意义(P>0.05);治疗后2组患儿CD4^+、CD8^+细胞含量明显上升(P<0.05),观察组上升更明显(P<0.05)。结论奥美拉唑治疗婴儿上消化道出血迅速有效,可以改善炎性指标及免疫指标,值得临床推广应用。Objective To analyze the effect of omeprazole on serum inflammatory factors and immune function in infants with upper gastrointestinal hemorrhage.Method Methods from December 2014 to December 2016,120 infants with upper gastrointestinal bleeding were treated in our hospital.The random number method was used as the control group and the observation group.The patients were divided into control group and observation group according to different treatment methods.The control group (60 cases)on the basis of routine treatment for 5 mg/kg cimetidine,2 times /day,the treatment group (60 cases)treated with omeprazole ling/on the basis of routine treatment (time kg) intravenous injection,2 times /day,for 5 days.The curative effect,inflammatory index and immune index of the two groups were observed and compared.Result Observation of effective 58 cases,the total effective rate was 96.67%;the control group was effective in all cases,the total effective rate was 46.67%,the observation group was significantly better than the control group (P <0.01).There was no significant difference in the contents of IL-2,IL-6 and TNF-α in the two groups before treatment (P >0.05).After treatment,the increase of IL-2 and the decrease of IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05).There was no significant difference between the two groups before the treatment of CD4^+,CD8^+ cell content (P >0.05);after treatment,the content of CD4^+ and CD8^+ cells in the two groups increased significantly (P <0.05);After treatment,the CD4^+ and CD8^+ cells in the observation group were significantly higher than those in the control group (P <0.05).Conclusion Omeprazole in the treatment of upper gastrointestinal bleeding in infants is rapid and effective,can improve the inflammatory index and immune index,it is worthy of clinical application.

关 键 词：上消化道出血 奥美拉唑 婴儿 炎性指标 

分 类 号：R72[医药卫生—儿科]