线粒体调控造血干细胞功能的研究进展  

Emerging role of Mitochondria in Maintenance of Hematopoietic Stem Cells

作　　者：刘子闲 董芳[1] 张森 韩明哲[1] 依马秀夫 LIU Zi-Xian;DONG Fang;ZHANG Sen;HAN Ming-Zhe;EMA Hideo(State Key Laboratory of Experimental Hematology ,Institute of Hematology &Blood Diseases Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College,Tianjin 300020,China)

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室,天津300020

出　　处：《中国实验血液学杂志》2019年第1期277-282,共6页Journal of Experimental Hematology

基　　金：国家自然科学基金(81500085;81670106;81470279;81670105;81421002;81730006);中国医学科学院医学与健康科技创新工程(2016-I2M-1-017;2017-I2M-1-015)

摘　　要：线粒体是真核细胞中特有的双层膜细胞器,其目前已知作用包括能量代谢、信号转导、细胞增殖与凋亡的调控等。近年来研究显示,线粒体在造血干细胞(hematopoietic stem cells,HSC)功能维持和细胞定向分化调节中发挥着重要作用:线粒体合成受限及线粒体及时清除是抵抗氧化应激、维持HSC稳态的重要手段;线粒体累积将导致HSC增殖甚至衰老;线粒体通过调节细胞内钙离子浓度调控HSC谱系分化。本文就以上相关内容进行详细探讨,旨在深入理解线粒体如何影响HSC的功能,为HSC的代谢调控研究提供理论参考。Mitochondria are double-membrane organelles existing only in eukaryotic cells. Mitochondria perform various important functions,such as producing energy,regulating signal transduction,and contributing to stress response. Recent studies have highlighted an important role of mitochondria in the determination of hematopoietic stem cells(HSC) fate. Limited biogenesis or timely clearance of mitochondria is an important way against oxidative stress,which favors the quiescence of HSC. Accumulation of mitochondria may lead to proliferation of HSC,even the aging of HSC. Mitochondrial signaling regulates Ca2+ concentration,which is essential for HSC differentiation. This review summarizes the current findings of the mitochondrial roles in HSC quiescence,self-renewal,lineage differentiation and aging.

关 键 词：线粒体 造血干细胞 静息状态 细胞分化 衰老 

分 类 号：R331.2[医药卫生—人体生理学] R329.28[医药卫生—基础医学]