间充质干细胞防治移植物抗宿主病的研究进展  

Ressarch Advances of Prevantive and Therapeatic Effect of Mesenchymal Stromal Cells on Graft-Versus-Host Disease

作　　者：王利[1,2] 马得勋 刘书锋 高春记 WANG Li;MA De-Xun;LIU Shu-Feng;GAO Chun-Ji(Department of Hematology,Chinese PLA General Hospital,Beijing 100853,China;Department of Hematology,Laoshan Branch of No.971 Hospital of Chinese PLA,Qingdao 266101,Shandong Province,China)

机构地区：[1]解放军总医院血液科,北京100853 [2]解放军第971医院崂山分院血液科,山东青岛266101

出　　处：《中国实验血液学杂志》2019年第1期283-287,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金面上项目(81270642;81070451);北京市自然科学基金面上项目(7162175);海南省社会发展基金(SF201306);解放军总医院百项优势项目(YS201451);军队后勤计划项目(cjn15j001)

摘　　要：移植物抗宿主病(GVHD)是异基因造血干细胞移植(allo-HSCT)后常见的严重并发症,严重影响移植的疗效及广泛应用。间充质干细胞(MSC)因其独特的免疫调节及组织修复能力成为allo-HSCT过程中GVHD预防及治疗的理想选择。本文就MSC防治GVHD的最新研究进展,MSC是否增加allo-HSCT后肿瘤复发及感染,影响MSC疗效的因素,MSC来源细胞外微囊对GVHD的防治作用等若干问题作一综述。Objective: Graft-versus-host disease(GVHD) is a frequently encountered serious complication after allogeneic hematopoietic stem cell transplantation(allo-HSCT), it limits the success and widespread use of allo-HSCT. Mesenchymal stem cells(MSCs) are selected as ideal prophylactic and treatment means for GVHD during allo-HSCT due to their unique immunomodulatory and regenerative properties. Herein, the recent research progress about the prevantive and therapeutic effects of MSCs on GVHD and several issues related with the applications of MSC, including whether MSCs increasing risk of primary disease relapse and infection, impact of several clinical parameters on the clinical response to MSCs, and the prevantive and therapeutic effect of MSC-derived extracellular vesicles on GVHD are systematically reviewed.

关 键 词：间充质干细胞 移植物抗宿主病 异基因造血干细胞移植 细胞外微囊 

分 类 号：R392.4[医药卫生—免疫学] R329.28[医药卫生—基础医学]