D二聚体、纤维蛋白原检测在预测急性心肌梗死PTCA支架术后再狭窄中的价值  

The Value of Detection of D-dimer and Fibrinogen in Predicting Restenosis in Patients with Acute Myocardial Infarction after PTCA Stenting

作　　者：周劲松[1] 钟远伦 李成玲 ZHOU Jing-song;ZHONG Yuan-lun;LI Cheng-ling(Department of Cardiovascular Medicine,people's Hospital,Gaoxian,Sichuan,Gaoxian,645150,China;Department of Cardiovascular Medicine,Yibin Hospital,Yibin 645150,China)

机构地区：[1]四川省高县人民医院心血管内科,高县645150 [2]宜宾市一医院心血管内科,宜宾645150

出　　处：《血栓与止血学》2018年第6期934-937,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的分析D二聚体(D-D)、纤维蛋白原(Fbg)在预测急性心肌梗死冠脉动脉腔内形成术(PTCA)支架术后再狭窄中的价值。方法回顾性分析2015年10月至2016年3月于我院接受PTCA支架术的82例患者的临床资料,所有患者手术前后均测定D-D、Fbg水平,分析D-D、Fbg与急性心肌梗死PTCA支架术后再狭窄发生的关系,总结急性心肌梗死PTCA支架术后再狭窄发生的相关危险因素。结果①82例患者均随访6个月,发生再狭窄18例,再狭窄发生率为21.95%;再狭窄组合并糖尿病、高脂血症所占比例高于非狭窄组(P <0.05)。②再狭窄组置入支架直径低于非狭窄组(P <0.05)。③术前、术后,再狭窄组D-D、Fbg均高于非狭窄组(P <0.05)。结论高Fbg、高D-D水平,且合并糖尿病、高脂血症患者其支架术后再狭窄发生风险较高,而置入大直径支架为术后再狭窄发生的保护因素。Objective To analyze the value of detection of D-dimer (D-D)and fibrinogen (Fbg)in predicting restenosis in patients with acute myocardial infarction after percutaneous translumenal coronary angioplasty(PTCA)stenting.Methods The clinical data of 82patients undergoing PTCA stenting in our hospital from October 2015to March 2016were retrospectively analyzed.Levels of D-D and Fbg were determined before and after operation,and the relationship between D-D,Fbg and restenosis after PTCA stenting for acute myocardial infarction was analyzed.The related risk factors of restenosis after PTCA stenting for acute myocardial infarction were summarized.Results All of the 82patients were followed up for 6months, and restenosis occurred in 18cases,the restenosis rate was 21.95%.The proportions of patients with diabetes and hyperlipidemia in restenosis group were higher than those in non-stenosis group (P <0..05 ).The diameter of stent implanted in restenosis group was shorter than that in non-stenosis group (P <0.05 ).The D-D and Fbg levels in restenosis group were higher than those in non-stenosis group before and after operation (P < 0.05 ).Conclusion The risk of restenosis after stenting is relatively higher in patients with high Fbg and high D-D levels,diabetes and hyperlipidemia,and the large-diameter stent implantation is the protective factor for restenosis after stenting.

关 键 词：急性心肌梗死 D二聚体 纤维蛋白原 再狭窄 

分 类 号：R542.22[医药卫生—心血管疾病]