乙醛脱氢酶2通过自噬修复器官缺血再灌注损伤的研究进展  

Injury of aldehyde dehydrogenase 2 in organ ischemiareperfusion injury through autophagy

作　　者：林丹妮 向涛 邱强民 许俊杰 钟自彪[1] 兰佳男[1] 薛帅[1] 胡前超 王彦峰[1] 叶啟发[1,2] Lin Danni;Xiang Tao;Qiu Qiangmin;Xa Junjie;Zhong Zibiao;Lan Jianan;Xue Shuai;Hu Qianchao;Wang Yanfeng;Ye Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China;The 3rd Xiangya Hospital of Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410000,China)

机构地区：[1]武汉大学中南医院武汉大学肝胆疾病研究院武汉大学移植医学中心移植医学技术湖北省重点实验室,430071 [2]中南大学湘雅三医院卫生部移植医学工程技术研究中心,长沙410000

出　　处：《中华肝胆外科杂志》2019年第1期77-80,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(81700657);国家自然科学基金-新疆联合基金(U1403222);国家级大学生创新创业训练计划项目(201710486109).

摘　　要：随着我国公民器官捐献的快速发展,心脏死亡器官捐献(DCD)供体器官已获广泛采用。为此,DCD供体的质量,包括如何保存、维护器官的质量亦成为目前面临的重大问题。缺血再灌注损伤对器官质量有着很大的影响。研究表明乙醛脱氢酶2(ALDH2)可在包括缺血再灌注损伤在内的众多应激条件下为各种器官提供保护,自噬的激活与抑制也可在不同应激条件的器官保护中发挥作用,而ALDH2则可通过调节自噬减少器官缺血再灌注损伤。本文旨在概述这种修复机制的研究进展。the rapid development of organ transplantation in China, the donation after cardiac death (DCD) donor organs are widely used. However, the quality of these organs is relatively poor, so the way to preserve and maintain organ still remains a severe problem. Among them, ischemic reperfusion injury (IRI) impairs the organs severely. Acetaldehyde dehydrogenase 2 (ALDH2) protects organs from stress conditions, including ischemia-reperfusion injury, and the activation and autophagy inhibition also protects the organs from stress conditions as well. Recent studies showed that ALDH2 can regulate autophagy to inhibit the organ injury during ischemia-reperfusion. Our study aims to discuss the new findings in this mechanism.

关 键 词：自噬 心脏死亡器官捐献 乙醛脱氢酶2 再灌注损伤 维护和修复 

分 类 号：R617[医药卫生—外科学]