抗原浓缩技术研究进展  

Research progress on concentration technology of antigen

作　　者：田宇杰 李银[1] 章丽娇 刘青涛[1] 韩凯凯[1] 杨婧[1] 刘宇卓[1] 赵冬敏[1] 刘娜[1] 王梦瑶 嵇辛勤[2] TIAN Yujie;LI Yin;ZHANG Lijiao;LIU Qingtao;HAN Kaikai;YANG Jing;LIU Yuzhuo;ZHAO Dongmin;LIU Na;WANG Mengyao;JI Xinqin(Institute of Veterinary Medicine,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China;College of Animal Science,Guizhou University,Guiyang 550025,China)

机构地区：[1]江苏省农业科学院兽医研究所,南京210014 [2]贵州大学动物科学学院,贵阳550025

出　　处：《黑龙江畜牧兽医》2019年第3期40-45,共6页Heilongjiang Animal Science And veterinary Medicine

基　　金：水禽重要疫病免疫防控新技术研究项目(2017YFD0500800)

摘　　要：动物疫病是危害养殖业发展的重要因素,而疫苗免疫又是目前防控动物疫病最有效的手段之一。为了提高兽用多联疫苗的免疫效力,去除杂质,减少临床上的免疫不良反应,需要对抗原进行浓缩。疫苗的抗原浓缩技术主要是通过物理或化学方法去除杂质以提高单位体积抗原含量,同时要防止抗原的免疫原性受到破坏,对整个浓缩条件要求较高,因此如何选择合适且高效的抗原浓缩方法尤为重要。文章对近年来抗原浓缩技术的研究及现状进行总结,旨在为选择抗原浓缩技术提供参考。Animal epidemic is the main factor which seriously threaten to the animal industry,and vaccine is the primary way to prevent from infection. To promote the efficacy of animal multi-vaccines as well as reduce clinical immunological adverse reaction,the antigens should be purified and concentrated. The antigen concentration technology mainly removes impurities by physical or chemical methods to increase the unit volume antigen content and prevent the immunogenicity of antigens from being destroyed. Therefore,how to select the optimal antigen enrichment method is particularly significant. In this review,the present situation of research on antigen enrichment technology in recent years were summarized, aiming to provide reference for its application.

关 键 词：抗原 蛋白质 浓缩 纯化 疫苗 

分 类 号：S852.43[农业科学—基础兽医学]