氟啶胺清洁合成工艺  

Clean Technology for Synthesis of Fluazinam

作　　者：冯广军[1] 王宝林[1] 王振峰 罗成燕[1] FENG Guang-jun;WANG Bao-lin;WANG Zhen-feng;LUO Cheng-yan(Jiangsu Yangnong Chemical Co.,Ltd.,Yangzhou 225009,Jiangsu,China)

机构地区：[1]江苏扬农化工股份有限公司,江苏扬州225009

出　　处：《农药》2019年第2期93-95,108,共4页Agrochemicals

摘　　要：[目的]对氟啶胺合成工艺进行清洁化研究。[方法]以2,3-二氯-5-三氟甲基吡啶为原料,通过加入能在氨水相和吡啶油相间起到传递作用的水溶性助剂,在较温和的反应条件下进行中间体2-氨基-3-氯-5-三氟甲基吡啶的合成,进一步与2,4-二氯-3,5-二硝基三氟甲苯缩合得到高效杀菌剂氟啶胺。[结果]氟啶胺合成工艺中,废水减排90%以上,并副产氯化铵和氯化钾盐。[结论]工艺过程清洁,适合工业化生产。[Aims] The clean process for the synthesis of fluazinam was studied. [Methods] Ammoniation was carried outwith2,3-dichloro-5-trifluoromethylpyridineasrawmaterial.Theintermediate2-amino-3-chloro-5-trifluoromethylpyridine was obtained under mild reaction conditions by adding water-soluble additives which could transfer between ammonia aqueous phase and pyridine oil phase. Highly effective fungicide fluazinam was synthesized by condensation2-amino-3-chloro-5-trifluoromethylpyridine with 2,4-dichloro-3,5-dinitrotrafluorotoluene. [Results] In the synthesis process of fluazinam, wastewater was reduced by more than 90%, and byproduct ammonium chloride and potassium chloride were received. [Conclusions] The process was clean and suitable for industrial production.

关 键 词：2-氨基-3-氯-5-三氟甲基吡啶 氟啶胺 清洁工艺 

分 类 号：TQ460.3[化学工程—制药化工]