人类精子核内胞质残留对受精后生殖活动的可能负效应  

Possible negative effects of human sperm intranuclear cytoplasmic retention on post-fertilization events

作　　者：朱伟杰[1] Zhu Weijie(Institute of Reproductive Immunology,College of Life Science and Technology,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学生命科学技术学院生殖免疫研究所,广州510632

出　　处：《中华生殖与避孕杂志》2019年第1期1-4,共4页Chinese Journal of Reproduction and Contraception

基　　金：广东省科技计划项目(2014A020213007).

摘　　要：人类精子核内含有残留胞质(INCR)。INCR起源于精子细胞变态过程的早期,是核内含有细胞质的一种隐匿性核异常类型。INCR是人类精子核内多见的超微现象,存在于精子核空泡内,具有大小、形状、数量、成分、位置和分布的多性样。畸形精子症的精子标本中,INCR发生率与精子头畸形率呈正相关。INCR可能通过多重机制对受精后的父本基因组活动和合子、早期胚胎发育产生负效应。应重视INCR可能对受精后生殖活动的影响,围绕INCR开展相关的实验与临床研究。The human sperm nucleus contains intranuclear cytoplasmic retention (INCR). INCR occurs in the early process of spermatiogenesis and is a hidden sperm nuclear alteration. Transmission electron microscopy revealed that INCR is a common ultrastructural phenomena within sperm nuclei. INCR existed in a nuclear vacuole and varied in size, number, shape, content, location, and distribution. In the teratozoospermia samples, the incidence of INCR exhibited a positive relationship with sperm abnormal morphology. INCR could play multiple harmful roles and contribute to deleterious impacts on post-fertilization events through different mechanisms. More experimental studies are needed to further elucidate INCR for basic and clinical aspects.

关 键 词：人类精子 胞质残留 细胞核 超微结构 精子变态 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]