卵泡液透明质酸水平与卵巢低储备人群获卵结果的相关性分析  

Correlation between hyaluronic acid in follicular fluid and oocyte retrieval outcome in patients with diminished ovarian reserve

作　　者：徐维海 舒静[2] 张岭[2] 张琳[2] 李施施[2] 金帆[1] Xu Weihai;Shu Jing;Zhang Ling;Zhang Lin;Li Shishi;Jin Fan(Women's Hospital School of Medicine,Zhejiang University,Hangzhou 310006,China;Zhejiang Province People's Hospital Hangzhou 310014,China)

机构地区：[1]浙江大学医学院附属妇产科医院,杭州310006 [2]浙江省人民医院,杭州310014

出　　处：《中华生殖与避孕杂志》2019年第1期54-56,共3页Chinese Journal of Reproduction and Contraception

基　　金：浙江省医药卫生科技计划项目(2017KY219);浙江省自然科学基金(LY15H260004).

摘　　要：目的 分析卵巢低储备患者卵泡液中透明质酸水平与取卵结果的相关性。 方法 测定34个未获卵卵泡液(研究组)和39个获卵卵泡液(对照组)的透明质酸和孕酮等指标,并测定人群血清抗苗勒管激素(AMH)。 结果 研究组血清AMH[(0.55±0.37) μg/L]水平低于对照组[(0.75±0.42) μg/L,P=0.033],卵泡液透明质酸浓度[(274±65) μg/L]低于对照组[(347±86) μg/L,P<0.001],孕酮水平[(91.4±25.3)×10^3 nmol/L]水平高于对照组[(81.3±15.6)×10^3 nmol/L,P=0.042]。 结论 卵巢低储备人群获卵失败与卵泡液透明质酸不足存在相关性。Objective To analyze the correlation between the concentration of hyaluronic acid in follicular fluid and oocyte retrieval results in the patients with diminished ovarian reserve. Methods The concentration of anti-Müllerian hormone (AMH) in serum, hyaluronic acid and progesterone in follicular fluid of 34 patients with none oocytes retrieved (study group) and 39 patients with successful retrieval (control group) were measured and compared. Results The concentration of AMH level [(0.55±0.37) μg/L] in serum and hyaluronic acid [(274±65) μg/L] in follicular fluid were lower than that in control group [(0.75±0.42) μg/L, P=0.033;(347±86) μg/L, P<0.001]. The level of progesterone in follicular fluid [(91.4±25.3)×10^3nmol/L] was higher than that in control group [(81.3±15.6)×10^3nmol/L, P=0.042]. Conclusion The failure of oocytes retrieval in diminished ovarian reserver is related to the insufficiency of hyaluronic acid in follicular fluid.

关 键 词：卵泡液 抗苗勒管激素(AMH)透明质酸 卵巢储备 

分 类 号：R714.8[医药卫生—妇产科学]