血清YKL-40、Hcy水平与CHD患者PCI术后发生不良心血管事件的相关性分析  

Correlation between Serum chondroprotein 39 ,Homocysteine and the Occurrence of MACE after PCI in Patients with CHD

作　　者：赵越超[1] 刘少奎[1] 王筱梅[1] ZHAO Yue-chao;LIU Shao-kui;WANG Xiao-mei(Zhongshan Hospital Affiliated to Dalian University,Liaoning 116001 China)

机构地区：[1]大连大学附属中山医院,辽宁大连116001

出　　处：《医学临床研究》2019年第1期98-100,共3页Journal of Clinical Research

摘　　要：【目的】 探讨血清人类软骨蛋白39(YKL-40)、同型半胱氨酸(Hcy)水平水平与冠心病(CHD)患者经皮冠脉介入术(PCI)术后发生主要心血管事件(MACE)的相关性。【方法】 选取2015年3月至2012年4月本院收治的104例行PCI治疗CHD患者的临床资料,根据术后12个月的随访结果将其分为观察组(发生MACE事件,n=34)和对照组(未发生MACE事件,n=70)。收集两组患者的一般资料,检测两组PCI术手术前后血清YKL-40、Hcy水平,并应用多因素Logistic回归分析MACE发生的危险因素。【结果】 两组年龄、性别、BMI、高血压、高血脂、吸烟、饮酒、CHD家族史方面比较,差异无统计学意义(P>0.05);观察组合并糖尿病、支架置入数目与对照组比较,差异具有统计学意义(P<0.05)。两组术前血清YKL-40、Hcy水平比较,差异无统计学意义(P>0.05);观察组术后24 h血清YKL-40、Hcy水平高于对照组,差异具有统计学意义(P<0.05)。PCI术后血清YKL-40、Hcy水平升高、置入支架数目>2、合并糖尿病是CHD患者PCI术后发生MACE事件的危险因素(P<0.05)。【结论】 行PCI术后发生MACE的CHD患者血清YKL-40、Hcy呈高水平表达,同时血清YKL-40、Hcy水平升高;置入支架数>2,合并糖尿病是CHD患者PCI术后发生MACE的危险因素。【Objective】 To investigate the relationship between serum levels of human chondroprotein 39 (YKL-40),homocysteine (Hcy) and the occurrence of major cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).【Methods】 The clinical data of 104 patients with CHD treated with PCI from March 2015 to April 2012 were selected. According to the results of 12 months follow-up, they were divided into two groups: the observation group (MACE event,n=34) and the control group (no MACE event,n=70). The general data of the two groups were collected and the serum YKL-40,Hcy levels were measured before and after PCI operation. Multivariate Logistic regression analysis was used to analyze the risk factors of MACE.【Results】 There was no significant difference in age, sex, BMI, hypertension, hyperlipidemia, smoking, alcohol consumption and CHD family history between the two groups (P>0.05). Compared with the control group, the number of stent implantation in the observation group was significantly different from that in the control group (P<0.05). There was no significant difference in serum YKL-40,Hcy levels between the two groups before operation (P>0.05). The serum YKL-40,Hcy level in the observation group was significantly higher than that in the control group at 24 hours after operation (P<0.05). The serum YKL-40,Hcy level was higher than that in the control group (P<0.05), and the number of stents implanted was more than 2. Diabetes mellitus was a risk factor for MACE events after PCI in patients with CHD (P<0.05). 【Conclusion】 The high- level expression of serum YKL-40,Hcy and the increase of serum YKL-40,Hcy, the number of stents>2 and diabetes mellitus are the risk factors of MACE after PCI in CHD patients.

关 键 词：冠心病 血管成形术 经腔 经皮冠状动脉 半胱氨酸/血液 软骨蛋白聚糖类/血液 

分 类 号：R541.4[医药卫生—心血管疾病]