慢性阻塞性肺疾病患者高分辨率CT下表型的临床特征分析  

Clinical characteristics and prognosis of chronic obstructive pulmonary disease phenotype classified by high resolution computer tomography

作　　者：马姣 石芳[1] 崔涛[1] 刘政[1] Ma Jiao;Shi Fang;Cui Tao;Liu Zheng(Department of Respiratory Medicine,China National Petroleum Corporation Central Hospital, Langfang 065000,China)

机构地区：[1]中国石油天然气集团公司中心医院呼吸科,廊坊065000

出　　处：《国际呼吸杂志》2019年第2期86-90,共5页International Journal of Respiration

基　　金：廊坊市科学技术研究与发展计划项目(2017013148).

摘　　要：目的通过高分辨率CT(HRCT)将慢性阻塞性肺疾病(COPD)患者分为不同的表型,探讨不同表型的临床特征以及预后。方法收集中国石油天然气集团公司中心医院呼吸科住院的COPD患者93例,通过HRCT将93例COPD患者分为A(n=51)、E(n=18)、M(n=24)3种表型,分析3组之间性别分布、COPD急性加重次数、红细胞沉降率(ESR)、血气分析、累积生存率的差异。结果(1)A型女性分布比率较E、M型高(χ^2=8.60、10.12,P值均<0.05),低衰减区域评分低于E、M型(χ^2=20.90、10.80,P值均<0.05);(2)M型ESR较A型高(F=10.98,P<0.05);(3)E型动脉血二氧化碳分压较A、M型高(F=7.80、5.60,P值均<0.05),E型累积生存率小于A、M型(χ^2=6.90、6.74,P值均<0.05)。结论根据HRCT对COPD进行表型分类,可以显示不同表型的临床特征以及预后的差异。Objective Chronic obstructive pulmonary disease (COPD) patients were divided into different phenotypes by high resolution computer tomography (HRCT) to investigate the clinical features and prognosis of different phenotype.Methods Ninety-three COPD patients were divided into three phenotype groups: A (n=51), E (n=18) and M (n=24) by HRCT, the differences of sex distribution, COPD exacerbations, erythrocyte sedimentation rate (ESR), blood gas analysis, and cumulative survival rate between the three groups were analyzed.Results (1)Femal distribution ratio was higher (χ^2=8.60, 10.12, both P<0.05) and LAA scores was lower (χ^2=20.90, 10.80, both P<0.05) in A phenotype than E and M phenotype.(2)ESR was higher in M phenotype than A phenotype (F=10.98, P<0.05). (3)Artery pressure of carbon dioxide as higher (F=7.80, 5.60, both P<0.05) and cumulative survival rate was lower in E phenotype than A and M phenotype (χ^2=6.90, 6.74, both P<0.05).Conclusions To divide COPD according to HRCT, the clinical features and prognosis are different in different COPD phenotypes.

关 键 词：肺疾病 慢性阻塞性 表型 高分辨率CT 

分 类 号：R563.9[医药卫生—呼吸系统] R816.41[医药卫生—内科学]