慢性阻塞性肺疾病急性加重期炎性生物标志物研究进展  

Progress in inflammatory biomarkers of chronic obstructive pulmonary disease with acute exacerbation

作　　者：王慧杰 徐武成 黄华琼[1] Wang Huijie;Xu Wucheng;Huang Huaqiong(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,China;Department of Respiratory Medicine,the First People's Hospital of Yuhang District,Hangzhou 311100,China)

机构地区：[1]浙江大学医学院附属第二医院呼吸与重症医学科,杭州310000 [2]余杭区第一人民医院呼吸科,杭州311100

出　　处：《国际呼吸杂志》2019年第2期134-138,共5页International Journal of Respiration

基　　金：国家重点研发计划“重大慢性非传染性疾病防控研究”专项课题(2017YFC1310604).

摘　　要：慢性阻塞性肺疾病(COPD)是一种呼吸系统常见的慢性疾病,在其发生发展过程中,炎症反应是导致一系列病理生理改变的重要机制。临床上评估慢性阻塞性肺疾病急性加重期(AECOPD)主要以临床症状改变为主,尚缺乏敏感的客观指标。研究发现多个炎症介质与AECOPD、病情严重程度和病情进展相关。现针对AECOPD潜在生物标记物作一综述,探讨这些炎症介质作为AECOPD生物标记物的价值和缺陷,旨在为临床提供AECOPD早期识别生物标记物和监测手段。Chronic obstructive pulmonary disease (COPD) is a common chronic disease in respiratory system.In the course of development, inflammatory response is an important mechanism leading to a series of pathophysiological changes.Clinical evaluation of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is mainly based on clinical symptoms and lack of sensitive objective indicators.Many studies found that multiple inflammatory mediators were associated with AECOPD, severity and progression of the disease.This paper summarizes the potential biomarkers of AECOPD, to investigate the value and defects of these inflammatory mediators as AECOPD biomarkers, aiming to provide early identification of biomarkers and monitoring methods for AECOPD.

关 键 词：肺疾病 慢性阻塞性 疾病进展 生物标志物 炎症介质 

分 类 号：R563.9[医药卫生—呼吸系统]