柯萨奇病毒A6所致手足口病研究现况  

Advances in research on hand,foot and mouth disease caused by coxsackievirus A6

作　　者：何鑫 杨婷[1] 谢忠平[1] HE Xin;YANG Ting;XIE Zhong-ping(Institute of Medical Biology, Chinese Academy of Medical Science and Peking Vnion Medical college, Kunming 650118 , China)

机构地区：[1]中国医学科学院北京协和医学院医学生物学研究所,云南昆明650118

出　　处：《中华疾病控制杂志》2018年第3期312-316,共5页Chinese Journal of Disease Control & Prevention

摘　　要：近年来,由柯萨奇病毒A6(coxsackievirus A6,Cox A6)引起的手足口病(hand,foot and mouth disease,HFMD)在全球多个国家以及我国多个地区暴发流行,已逐渐为引起HFMD的主要病原之一。Cox A6不仅能感染3岁以下的儿童,也可对成年人造成严重伤害。脱甲是Cox A6感染所致HFMD的常见临床表现,其严重病例多出现神经系统症状,并发无菌性脑膜炎、脑炎。此外,Cox A6感染导致皮肤损害的程度更为严重。由于目前针对Cox A6的研究尚不全面,尤其是关于Cox A6致病机理及动物模型的研究资料较少,因此,对Cox A6的相关研究进行总结和归纳,为今后Cox A6所致HFMD的防治奠定基础,为Cox A6预防疫苗的研发提供新思路。现就Cox A6目前的流行概况、病毒感染、临床症状、疫苗研发等作一综述。In recent years,coxsackievirus A6( CoxA6) has outbreaken in many countries and some areas of China. It has gradually emerged as a major pathogen of hand-foot-mouth disease( HFMD),causing widespread concern around the world. CoxA6 not only infects children under 5 years of age,but also can cause serious harm to adults. Detoxification is a common clinical manifestation of HFMD caused by CoxA6. In severe cases,neurological symptoms,aseptic meningitis and encephalitis occur. In addition,CoxA6 infection can cause more severe skin lesions. However,the current researches on CoxA6 are not comprehensive,especially about the pathogenesis and animal models of CoxA6. Therefore,summarizing the related researches of CoxA6 will lay the foundation for the future preventions and treatments of CoxA6-induced HFMD,and it can also provide a new idea for the development of CoxA6 vaccine. This review aims to provide an overview of the current prevalence of CoxA6,CoxA6 virus infection,the clinical symptoms,as well as the researches of CoxA6 vaccine.

关 键 词：柯萨奇病毒A6 手足口病 重组 

分 类 号：R512.57[医药卫生—内科学]