环孢菌素A菌渣无害化减量化技术研究  

The reduction and harmlessness of cyclosporin A residue by waste minimization

作　　者：王欣荣 张雪霞[2] 褚以文 郑智慧[2] 苟小军 路新华[2] 王勇军 Wang Xin-rong;Zhang Xue-xia;Chu Vi-wen;Zheng Zhi-hui;Gou Xiao-jun;Lu Xin-hua;Wang Yong-jun(Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics,Chengdu 610052;Noah China Pharmaceutical Group New Drug Research & Development Co.,Ltd,Shijiazhuang 050015)

机构地区：[1]抗生素研究与再评价四川省重点实验室四川抗菌素工业研究所,成都610052 [2]华北制药集团新药研究开发有限责任公司,石家庄050015

出　　处：《中国抗生素杂志》2019年第2期214-217,共4页Chinese Journal of Antibiotics

基　　金：成都市"新抗生素创制及产业化协同创新"项目(No.2016-XT00-00023-GX)

摘　　要：目的采用嗜热微生物处理环孢菌素菌渣,实现环孢菌素生产过程中的菌渣减量排放。方法将培养好的厌氧芽孢杆菌(Anoxybacillus mongoliensis SIIA-1501a)、土芽孢杆菌(Geobacillus sp. SIIA-1501g)和极端嗜热菌(Calditerricola yamamurae SIIA-1501c)依次分期加入环孢菌素菌渣堆肥培养,使菌渣减量化,并使菌渣中的环孢菌素残留降低。结果环孢菌素菌渣经过厌氧芽孢杆菌堆肥处理5～8d,嗜热地芽孢杆菌堆肥处理4～7d和极端嗜热菌堆肥处理4～6d,环孢菌素菌渣减量80%以上,废渣中环孢菌素残留去除率近99%。结论采用三联菌处理环孢菌素菌渣,实现了无害化和减量化,废渣中环孢菌素残留基本去除,具备较好的环境效益和社会效益。Objective To reduce the emission of cyclosporin A residue, the bacterial residue was treated with thermophilic microorganisms. Methods The bacterial residue of cyclosporin A was treated with Anoxybacillus mongoliensis SIIA-1501a, Geobacillus sp. SIIA-1501g and Calditerricola yamamurae SIIA-1501c to reduce the bacterial residue and the residual quantity of cyclosporin A inside the bacterial residue. Results The bacterial residue of cyclosporin A was reduced by more than 80% after composted with Anoxybacillus mongoliensis SIIA-1501a, Geobacillus sp. SIIA-1501g and Calditerricola yamamurae SIIA-1501c from day 4 to day 8 successively. The residual quantity of cyclosporin A inside the bacterial residue was also decreased by more than 95%. Conclusion This study demonstrated a novel method to reduce the emission of cyclosporin A residue by the combination of three different bacterial strains, which might provide the economic benefits and social effects for antibiotics research.

关 键 词：嗜热微生物 菌渣处理 无害化 减量化 环孢菌素 

分 类 号：R978[医药卫生—药品]