3889份住院患者血培养病原菌分布及耐药性分析  

Distribution of pathogenic bacteria in 3,889 hospitalized patients and analysis of drug resistance

作　　者：陈国敏[1] 王东辰[2] 许会彬[1] 邱玉玉[3] 李晓霞[3] Chen Guo-min;Wang Dong-chen;Xu Hui-bin;Qiu Yu-yu;Li Xiao-xia(Clinical Laboratory of PLA No.88 Hospital,Tai'an 271000;Orthopedics Center of PLANo.88 Hospital,Tai'an 271000;College of Basic Medicine,TaiShan Medical University,Tai'an 271000)

机构地区：[1]解放军第88医院检验科,泰安271000 [2]解放军第88医院骨科中心,泰安271000 [3]泰山医学院基础医学部,泰安271000

出　　处：《中国抗生素杂志》2019年第2期266-269,共4页Chinese Journal of Antibiotics

基　　金：山东省自然科学基金(No.ZR2014HL089)

摘　　要：目的了解临床送检血培养标本的病原菌分布及耐药特点。方法回顾分析我院2016年1月—2017年12月临床送检的3889份血培养标本。结果 3889份血培养标本共检出病原菌438株,阳性率为11.26%。其中革兰阴性菌共检出273株,占62.33%,革兰阳性菌共138株,占31.51%,真菌15株,占3.42%,革兰阳性菌12株,占2.74%,无专性厌氧菌的检出;阳性率前3位的科室分别是肾内科、ICU和肝病科;分离率前3位的细菌是大肠埃希菌、金黄色葡萄球菌和肺炎克雷伯菌。结论定期对血培养病原菌的分布及耐药情况进行分析,为临床提供一手资料,以降低血流感染的病死率,提高治疗效果。Objective To understand the characteristics of the distribution and drug resistance of pathogens. Methods Retrospectively, the 3,889 blood culture samples that were tested in our hospital from January 2016 to December 2017 were analyzed. Results 438 out of 3,889 blood culture samples were found with pathogens, in other words, the positive rate is 11.26%. To be more specific, 273 out of 438 samples were found with Gram-negative bacilli, which were 62.33% of the total. 138 (31.51%) samples were seen with the occurrence of Gram-positive cocci. The rest were 15 (3.42%) strains of fungus and 12 (2.74%) strains of Gram-positive bacilli. No specific anaerobes were detected. The top-three department judged by the rate of occurrence were the Nephrology Department, the Intensive Care Unit (ICU), and the Hepatic Department. Conclusion The characteristics of the distribution and drug resistance of pathogens should be regularly analyzed to offer the in-time data to the clinic, which could help to reduce the rate of death caused by bloodstream infections. Furthermore, the result of treatments should be improved.

关 键 词：血流感染 耐药性 细菌分布 抗菌药物 

分 类 号：R37[医药卫生—病原生物学] R978.1[医药卫生—基础医学]