微小RNA调控胰岛β细胞增殖的研究进展  

Advances of the regulation of islet β cell proliferation by microRNA

作　　者：刘翠莲 杨浩然 王绍文[1] 阮庆国 LIU Cuilian;YANG Haoran;WANG Shaowen(Center for Antibody Drug,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)

机构地区：[1]中国科学院深圳先进技术研究院抗体药物研究中心,深圳518055 [2]山东省眼科研究所

出　　处：《中国糖尿病杂志》2019年第1期69-72,共4页Chinese Journal of Diabetes

基　　金：深圳市基础研究项目(JCYJ20170413165432016)

摘　　要：功能性胰岛β细胞数量不足是糖尿病发生的主要原因,恢复胰岛β细胞数量成为治疗糖尿病的重要目标。胰岛β细胞的增殖高峰期发生在胚胎后期和新生儿期。在特定条件下,如肥胖等,胰岛β细胞增殖是其再生的重要途径。微小RNA(miRNA)是一类非编码小分子RNA,参与基因表达的转录后调控,miRNA在妊娠期和糖尿病等各种生理和病理调控中发挥重要作用。本文将对miRNA在调控胰岛β细胞增殖中的作用进行综述。The lack of functional islet β cells is a critical cause of diabetes. Thus,restoring the number of β cells has become an important goal for diabetes treatment. The peak time of β cell selfproliferation occurs in the late embryo and neonatal period. However,under certain conditions such as obesity,β cell self-proliferation is also an important way of adult β cell regeneration. microRNA(miRNA)is a class of short non-coding RNA molecules that are involved in post-transcriptional regulation of gene expression. miRNA plays an important role in various physiological and pathological processes such as pregnancy and diabetes. In this review article,we will summarize the advances of the regulation of β cell proliferation by miRNA.

关 键 词：微小RNA 胰岛Β细胞 细胞增殖 

分 类 号：R587.1[医药卫生—内分泌]