IL-17/Th17细胞在1型糖尿病中的潜在致病作用  

Potential pathogenic role of IL-17/Th17 cells in type 1 diabetes mellitus

作　　者：王玉洁 宋海燕[1] WANG Yujie;SONG Haiyan.(Department of Endocrinology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086, China)

机构地区：[1]哈尔滨医科大学附属第二医院内分泌科,150086

出　　处：《中国糖尿病杂志》2019年第1期77-80,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81370903)

摘　　要：胰岛β细胞的自身免疫破坏与T细胞的免疫耐受破坏有关,其中辅助性T细胞17型(Th17)细胞是重要的分泌白介素17(IL-17)的促炎性CD4+T细胞亚群。Th17细胞在T1DM病因中起重要作用,指定阻断Th17细胞分化的小分子是T1DM的潜在治疗剂。本文对IL-17/Th17细胞在T1DM中的潜在致病作用进行评述。It is known that autoimmune destruction of pancreatic β-cells is associated with the destruction of T-cell immune tolerance. T helper 17 type(Th17)cells are an important subset of pro-inflammatory CD4+T cell that secrete interleukin 17(IL-17). There are evidences supporting a definitive role of Th17 cells in the etiology of type 1 diabetes(T1 DM). Recently,small molecules that specifically block Th17 cells differentiation were considered as potential therapeutics of T1 DM. This article reviews the potential pathogenic role of IL-17/Th17 cells on T1 DM and its clinical application prospects.

关 键 词：辅助性T细胞17型 白介素17 糖尿病 1型 调节性T细胞 

分 类 号：R587.1[医药卫生—内分泌]