苦参功劳颗粒的体内抗菌试验研究  

Experimental study on the antibacterial effect of Kushengonglao granule in vivo

作　　者：高艳艳 潘贵珍 李召斌 张珍 刘兴金 GAO Yanyan;PAN Guizhen;LI Zhaobin;ZHANG Zhen;LIU Xingjin(Luoyang Huizhong Animal Medicine Co.Ltd, Luoyang Henan 471003, China;Pulike Biological engineering Co.Ltd, Luoyang Henan 471003, China)

机构地区：[1]洛阳惠中兽药有限公司,河南洛阳471003 [2]普莱柯生物工程股份有限公司,河南洛阳471003

出　　处：《中兽医医药杂志》2019年第1期38-42,共5页Journal of Traditional Chinese Veterinary Medicine

基　　金："十一五"国家科技支撑计划"中兽药现代化技术研究与开发"(2008BADB4B00)

摘　　要：为了考察苦参功劳颗粒的抗菌作用,用大肠杆菌标准菌株C83694建立小鼠人工感染模型,利用该模型考察苦参功劳颗粒低、中、高3个给药剂量对小鼠人工感染大肠杆菌病的治疗作用,评价苦参功劳颗粒的抗菌作用。结果表明,苦参功劳颗粒按0.3 g/kg、0.6 g/kg、1.2g/kg灌胃给药,可显著降低人工感染大肠杆菌病引起的小鼠死亡,对小鼠人工感染大肠杆菌病具有治疗作用。结论:苦参功劳颗粒具有抗大肠杆菌的作用,同时为苦参功劳颗粒的临床应用提供参考。The purpose of this study was to evaluate the antibacterial activity of Kushengonglaog ranule against E. coli. The standard strain C83694 was used for establishing E.coli disease model in mice. Three different dosages of Kushengonglao granule was administrated to the infected mice. After oral administration,the cure rates of infected mice with the dosage 0.3 g/kg,0.6 g/kg,and 1.2 g/kg respectively. The results of this study suggest that Kushengonglao granule was a promising antibacterial agent for the treatment of E.coli infections,and could be used to inform its clinical use.

关 键 词：苦参功劳颗粒 大肠杆菌 人工感染 

分 类 号：S853.9[农业科学—临床兽医学]